Time To Split Up: Dynamics of Chromosome Separation

被引：21

作者：

Kamenz, Julia ^{[1
]}

Hauf, Silke ^{[2
,3
]}

机构：

[1] Stanford Univ, Dept Chem & Syst Biol, Sch Med, Stanford, CA 94305 USA

[2] Virginia Tech, Dept Biol Sci, Blacksburg, VA 24061 USA

[3] Virginia Tech, Biocomplex Inst, Blacksburg, VA 24061 USA

来源：

TRENDS IN CELL BIOLOGY | 2017年 / 27卷 / 01期

关键词：

SISTER-CHROMATID SEPARATION; COHESIN SUBUNIT SCC1; MITOTIC EXIT; HUMAN-CELLS; CENTRIOLE DISENGAGEMENT; ANAPHASE PROGRESSION; SPINDLE ELONGATION; MAMMALIAN-CELLS; BUDDING YEAST; AUTO-CLEAVAGE;

D O I：

10.1016/j.tcb.2016.07.008

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The separation of chromosomes in anaphase is a precarious step in the cell cycle. The separation is irreversible, and any error can lead to cell death or genetic instability. Chromosome separation is controlled by the protease separase. Here we discuss recent work that has revealed additional layers of separase regulation and has deepened our understanding of how separase activation is coordinated with other events of mitotic exit.

引用

页码：42 / 54

页数：13

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