Adsorption Kinetics, Mechanism, Isotherm, and Thermodynamic Analysis of Paclitaxel from Extracts of Taxus chinensis Cell Cultures onto Sylopute

被引:41
作者
Kang, Hoe-Jong [1 ]
Kim, Jin-Hyun [1 ]
机构
[1] Kongju Natl Univ, Dept Chem Engn, Cheonan 330717, South Korea
基金
新加坡国家研究基金会;
关键词
paclitaxel; Sylopute; adsorption isotherm; kinetics; thermodynamics; ULTRASOUND-ASSISTED EXTRACTION; AQUEOUS-SOLUTION; REMOVAL; PURIFICATION; BIOSORPTION; SILICA;
D O I
10.1007/s12257-019-0001-1
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
The adsorption characteristics of paclitaxel from extracts of Taxus chinensis cell cultures by the commercial adsorbent Sylopute were investigated using different parameters such as initial paclitaxel concentration, adsorption temperature, and contact time. The equilibrium adsorption data were best represented with the highest accuracy (r(2) > 0.984, RMSD<0.0009) by the Langmuir isotherm. It was found that the adsorption capacity increased with increasing temperatures and the adsorption of paclitaxel onto Sylopute was favorable. The kinetic data fit the pseudo-second-order model well, and intraparticle diffusion played a dominant role in paclitaxel adsorption according to the intraparticle diffusion model. Thermodynamic parameters such as Delta H-0, Delta S-0, and Delta G(0) were also calculated. The results indicate that the process of paclitaxel adsorption onto Sylopute is endothermic and nonspontaneous. The isosteric heat of adsorption, Delta H-x (20-25 kJ/mol), was nearly a constant, even with variations in surface loading (q(e): 3-9 mg/g), indicating a homogeneous surface.
引用
收藏
页码:513 / 521
页数:9
相关论文
共 36 条
[1]   Isotherm, kinetic, and thermodynamic studies on the adsorption behavior of 10-deacetylpaclitaxel onto Sylopute [J].
Bang, Su-Yeon ;
Kim, Jin-Hyun .
BIOTECHNOLOGY AND BIOPROCESS ENGINEERING, 2017, 22 (05) :620-630
[2]  
Choi H.-K., 2002, J. Plant Biotechnol, V29, P59, DOI [10.5010/JPB.2002.29.1.059, DOI 10.5010/JPB.2002.29.1.059]
[3]   Effect of drying methods on removal of residual solvents from solvent-induced amorphous paclitaxel [J].
Choi, Myung-Geun ;
Kim, Jin-Hyun .
KOREAN JOURNAL OF CHEMICAL ENGINEERING, 2017, 34 (12) :3041-3047
[4]   Adsorptive removal of polyphenols from an alfalfa white proteins concentrate: Adsorbent screening, adsorption kinetics and equilibrium study [J].
Firdaous, L. ;
Fertin, B. ;
Khelissa, O. ;
Dhainaut, M. ;
Nedjar, N. ;
Chataigne, G. ;
Ouhoud, L. ;
Lutin, F. ;
Dhulster, P. .
SEPARATION AND PURIFICATION TECHNOLOGY, 2017, 178 :29-39
[5]   Insights into the modeling of adsorption isotherm systems [J].
Foo, K. Y. ;
Hameed, B. H. .
CHEMICAL ENGINEERING JOURNAL, 2010, 156 (01) :2-10
[6]   Kinetic and thermodynamic characteristics of ultrasound-assisted extraction for recovery of paclitaxel from biomass [J].
Ha, Geon-Soo ;
Kim, Jin-Hyun .
PROCESS BIOCHEMISTRY, 2016, 51 (10) :1664-1673
[7]   Adsorption of taxol into ordered mesoporous silicas with various pore diameters [J].
Hata, H ;
Saeki, S ;
Kimura, T ;
Sugahara, Y ;
Kuroda, K .
CHEMISTRY OF MATERIALS, 1999, 11 (04) :1110-1119
[8]   Synthesis of mesoporous spherical silica via spray pyrolysis: Pore size control and evaluation of performance in paclitaxel pre-purification [J].
Jang, Hye Ran ;
Oh, Hyeon-Jeong ;
Kim, Jin-Hyun ;
Jung, Kyeong Youl .
MICROPOROUS AND MESOPOROUS MATERIALS, 2013, 165 :219-227
[9]  
Kim Gun-Joong, 2013, Korean Journal of Microbiology and Biotechnology, V41, P272, DOI 10.4014/kjmb.1303.03001
[10]   Kinetics and thermodynamics of microwave-assisted drying of paclitaxel for removal of residual methylene chloride [J].
Kim, Hee-Soo ;
Kim, Jin-Hyun .
PROCESS BIOCHEMISTRY, 2017, 56 :163-170