Improved survival and antagonistic effect of sodium fusidate on tumor necrosis factor alpha in a neonatal mouse model of endotoxin shock

被引：19
|
作者：
Genovese, F
Mancuso, G
Cuzzola, M
Cusumano, V
Nicoletti, F
Bendtzen, K
Teti, G
机构：
[1] UNIV COPENHAGEN, RIGSHOSP, INST INFLAMMAT RES TA7544, DK-2200 COPENHAGEN N, DENMARK
[2] UNIV MESSINA, INST MICROBIOL, MESSINA, ITALY
[3] UNIV MILAN, INST MICROBIOL, MILAN, ITALY
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1996年 / 40卷 / 07期
关键词：
D O I：
10.1128/AAC.40.7.1733
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Unlike the antibiotics erythromycin and penicillin G, sodium fusidate (fusidin) pretreatment (80 mg/kg of body weight) increased the survival rate of neonatal BALB/c mice challenged with Salmonella enteritidis lipopolysaccharide. Fusidin also significantly reduced the plasma tumor necrosis factor alpha levels. Hence, fusidin may prove useful in the management of bacterial sepsis in humans.
引用
收藏
页码：1733 / 1735
页数：3
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