Optimization of integrated chromatography sequences for purification of biopharmaceuticals

被引：8

作者：

Lofgren, Anton ^{[1
]}

Yamanee-Nolin, Mikael ^{[1
]}

Tallvod, Simon ^{[1
]}

Fons, Joaquin G. ^{[1
]}

Andersson, Niklas ^{[1
]}

Nilsson, Bernt ^{[1
]}

机构：

[1] Lund Univ, Dept Chem Engn, POB 124, SE-21100 Lund, Sweden

来源：

BIOTECHNOLOGY PROGRESS | 2019年 / 35卷 / 06期

关键词：

chromatography; continuous bioprocessing; integrated column sequences; multiple column design; optimization; DESIGN;

D O I：

10.1002/btpr.2871

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

With continued development of integrated and continuous downstream purification processes, tuning and optimization become increasingly complicated with additional parameters and codependent variables over the sequence. This article offers a novel perspective of nonlinear optimization of integrated sequences with regard to individual column sizes, flow rates, and scheduling. The problem setup itself is a versatile tool to be used in downstream design which is demonstrated in two case studies: a four-column integrated sequence and a continuously loaded twin-capture setup with five columns.

引用

页数：7

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