Optimization of integrated chromatography sequences for purification of biopharmaceuticals

被引：8

作者：

Lofgren, Anton ^{[1
]}

Yamanee-Nolin, Mikael ^{[1
]}

Tallvod, Simon ^{[1
]}

Fons, Joaquin G. ^{[1
]}

Andersson, Niklas ^{[1
]}

Nilsson, Bernt ^{[1
]}

机构：

[1] Lund Univ, Dept Chem Engn, POB 124, SE-21100 Lund, Sweden

来源：

BIOTECHNOLOGY PROGRESS | 2019年 / 35卷 / 06期

关键词：

chromatography; continuous bioprocessing; integrated column sequences; multiple column design; optimization; DESIGN;

D O I：

10.1002/btpr.2871

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

With continued development of integrated and continuous downstream purification processes, tuning and optimization become increasingly complicated with additional parameters and codependent variables over the sequence. This article offers a novel perspective of nonlinear optimization of integrated sequences with regard to individual column sizes, flow rates, and scheduling. The problem setup itself is a versatile tool to be used in downstream design which is demonstrated in two case studies: a four-column integrated sequence and a continuously loaded twin-capture setup with five columns.

引用

页数：7

共 50 条

[11] Recent developments in chromatographic purification of biopharmaceuticals
Rathore, Anurag S.
Kumar, Devashish
Kateja, Nikhil
BIOTECHNOLOGY LETTERS, 2018, 40 (06) : 895 - 905
[12] Elevated temperature chromatography for improved purification of hydrophobic and long sequences
Simpson, Colin
Cesta, Drew
Singh, Sandeep
Collins, Jon
JOURNAL OF PEPTIDE SCIENCE, 2024, 30
[13] Product focus: Integrated chromatography system for peptide purification
不详
CHIMICA OGGI-CHEMISTRY TODAY, 1997, 15 (9-10) : 58 - 60
[14] Integrated multidimensional chromatography on preparative scale for oligonucleotides purification
Nosengo, Chiara
Bozza, Desiree
Lievore, Giulio
Vogg, Sebastian
Catani, Martina
Cavazzini, Alberto
Muller-Spath, Thomas
De Luca, Chiara
Felletti, Simona
JOURNAL OF CHROMATOGRAPHY A, 2024, 1737
[15] New disposable technology for the chromatographic purification of biopharmaceuticals
Amara, John P.
Yavorsky, David P.
Cacace, Benjamin P.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2013, 245
[16] Ionic liquids as solvents and ligands in the purification of biopharmaceuticals
Freire, Mara G.
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 2021, 50 (SUPPL 1): : 69 - 69
[17] Biopharmaceuticals from microorganisms: from production to purification
Jozala, Angela Faustino
Geraldes, Danilo Costa
Tundisi, Louise Lacalendola
Feitosa, Valker de Araujo
Breyer, Carlos Alexandre
Cardoso, Samuel Leite
Mazzola, Priscila Gava
de Oliveira-Nascimento, Laura
Rangel-Yagui, Carlota de Oliveira
Magalhaes, Perola de Oliveira
de Oliveira, Marcos Antonio
Pessoa, Adalberto, Jr.
BRAZILIAN JOURNAL OF MICROBIOLOGY, 2016, 47 : 51 - 63
[18] Minicircle Biopharmaceuticals-An Overview of Purification Strategies
Alves, Claudia P. A.
Prazeres, Duarte Miguel F.
Monteiro, Gabriel A.
FRONTIERS IN CHEMICAL ENGINEERING, 2021, 2
[19] Renaissance of protein crystallization and precipitation in biopharmaceuticals purification
dos Santos, Raquel
Carvalho, Ana Luisa
Roque, A. Cecilia A.
BIOTECHNOLOGY ADVANCES, 2017, 35 (01) : 41 - 50
[20] Ion-exchange chromatography for the characterization of biopharmaceuticals
Fekete, Szabolcs
Beck, Alain
Veuthey, Jean-Luc
Guillarme, Davy
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2015, 113 : 43 - 55

← 1 2 3 4 5 →