Optimization of integrated chromatography sequences for purification of biopharmaceuticals

被引：8
|
作者：
Lofgren, Anton [1 ]
Yamanee-Nolin, Mikael [1 ]
Tallvod, Simon [1 ]
Fons, Joaquin G. [1 ]
Andersson, Niklas [1 ]
Nilsson, Bernt [1 ]
机构：
[1] Lund Univ, Dept Chem Engn, POB 124, SE-21100 Lund, Sweden
来源：
BIOTECHNOLOGY PROGRESS | 2019年 / 35卷 / 06期
关键词：
chromatography; continuous bioprocessing; integrated column sequences; multiple column design; optimization; DESIGN;
D O I：
10.1002/btpr.2871
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
With continued development of integrated and continuous downstream purification processes, tuning and optimization become increasingly complicated with additional parameters and codependent variables over the sequence. This article offers a novel perspective of nonlinear optimization of integrated sequences with regard to individual column sizes, flow rates, and scheduling. The problem setup itself is a versatile tool to be used in downstream design which is demonstrated in two case studies: a four-column integrated sequence and a continuously loaded twin-capture setup with five columns.
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页数：7
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