Toward the Design of Smart Delivery Systems Controlled by Integrated Enzyme-Based Biocomputing Ensembles

被引：102

作者：

Diez, Paula ^{[1
]}

Sanchez, Alfredo ^{[1
]}

Gamella, Maria ^{[1
]}

Martinez-Ruiz, Paloma ^{[2
]}

Aznar, Elena ^{[3
,4
,5
]}

de la Torre, Cristina ^{[3
,4
,5
]}

Murguia, Jose R. ^{[3
,4
,5
]}

Martinez-Manez, Ramon ^{[3
,4
,5
]}

Villalonga, Reynaldo ^{[1
,6
]}

Pingarron, Jose M. ^{[1
,6
]}

机构：

[1] Univ Complutense Madrid, Fac Chem, Dept Analyt Chem, E-28040 Madrid, Spain

[2] Univ Complutense Madrid, Fac Chem, Dept Organ Chem 1, E-28040 Madrid, Spain

[3] Univ Valencia, Univ Politecn Valencia, Ctr Mixto, Inst Reconocimiento Mol & Desarrollo Tecnol IDM, Valencia 46022, Spain

[4] Univ Politecn Valencia, Dept Quim, Valencia 46022, Spain

[5] Univ Politecn Valencia, CIBER Bioingn Biomat & Nanomed CIBER BBN, Valencia 46022, Spain

[6] City Univ Cantoblanco, IMDEA Nanosci, Madrid 28049, Spain

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2014年 / 136卷 / 25期

关键词：

MESOPOROUS SILICA NANOPARTICLES; RESPONSIVE CONTROLLED-RELEASE; DRUG-DELIVERY; GUEST MOLECULES; BENZIMIDAZOLE; THERAPY; DRIVEN;

D O I：

10.1021/ja503578b

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report herein the design of a smart delivery system in which cargo delivery from capped mesoporous silica (MS) nanoparticles is controlled by an integrated enzyme-based "control unit". The system consists of Janus-type nanoparticles having opposing Au and MS faces, functionalized with a pH-responsive beta-cyclodextrin-based supramolecular nanovalve on the MS surface and two effectors, glucose oxidase and esterase, immobilized on the Au face. The nanodevice behaves as an enzymatic logical OR operator which is selectively fueled by the presence of D-glucose and ethyl butyrate.

引用

页码：9116 / 9123

页数：8

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