COVID-19 and Oxidative Stress

被引：188

作者：

Chernyak, B., V ^{[1
]}

Popova, E. N. ^{[1
]}

Prikhodko, A. S. ^{[1
,2
]}

Grebenchikov, O. A. ^{[3
]}

Zinovkina, L. A. ^{[2
]}

Zinovkin, R. A. ^{[1
,4
,5
]}

机构：

[1] Lomonosov Moscow State Univ, Belozersky Inst Physicochem Biol, Moscow 119991, Russia

[2] Lomonosov Moscow State Univ, Fac Bioengn & Bioinformat, Moscow 119991, Russia

[3] Negovsky Sci Res Inst Gen Reanimatol, Moscow 107031, Russia

[4] Lomonosov Moscow State Univ, Inst Mitoengn, Moscow 119992, Russia

[5] Sechenov First Moscow State Med Univ, Inst Mol Med, Moscow 119991, Russia

来源：

BIOCHEMISTRY-MOSCOW | 2020年 / 85卷 / 12-13期

基金：

俄罗斯基础研究基金会;

关键词：

oxidative stress; endothelium; SARS-CoV-2; COVID-19; cytokine storm; NF-KAPPA-B; INDUCED ENDOTHELIAL PERMEABILITY; TRANSCRIPTION FACTOR NRF2; ANGIOTENSIN-II; TNF-ALPHA; SIGNAL-TRANSDUCTION; EPITHELIAL-CELLS; NITRIC-OXIDE; LUNG INJURY; INFLAMMATORY ACTIVATION;

D O I：

10.1134/S0006297920120068

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pathogenesis of the novel coronavirus infection COVID-19 is the subject of active research around the world. COVID-19 caused by the SARS-CoV-2 is a complex disease in which interaction of the virus with target cells, action of the immune system and the body's systemic response to these events are closely intertwined. Many respiratory viral infections, including COVID-19, cause death of the infected cells, activation of innate immune response, and secretion of inflammatory cytokines. All these processes are associated with the development of oxidative stress, which makes an important contribution to pathogenesis of the viral infections. This review analyzes information on the oxidative stress associated with the infections caused by SARS-CoV-2 and other respiratory viruses. The review also focuses on involvement of the vascular endothelium in the COVID-19 pathogenesis.

引用

页码：1543 / 1553

页数：11

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