Transforming growth factor beta 1, interleukin-8 and interleukin-1 in non-small-cell lung tumors

被引：34
|
作者：
Colasante, A [1 ]
Mascetra, N [1 ]
Brunetti, M [1 ]
Lattanzio, G [1 ]
Diodoro, M [1 ]
Caltagirone, S [1 ]
Musiani, P [1 ]
Aiello, FB [1 ]
机构：
[1] UNIV G DANNUNZIO,DEPT PATHOL,CHIETI,ITALY
来源：
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE | 1997年 / 156卷 / 03期
关键词：
D O I：
10.1164/ajrccm.156.3.9701122
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
A role in tumor progression has been proposed for transforming growth fractor-beta 1 (TGF beta 1) and interleukin (IL)-8 as well as for IL-1, which itself induces the production of TGF beta 1 and IL-8 in many cell types. TGF beta 1 and IL-8 production and their regulation by IL-1 in five non-small-cell (NSC) lung tumor cell lines were evaluated. Moreover, their levels were evaluated in 29 NSC lung tumors. All cell lines constitutively produced TGF beta 1, and three produced IL-8. After IL-1 beta treatment, TGF beta 1 production was upregulated in two cell lines, whereas IL-8 production was markedly upregulated in two, induced in one, and unmodified in two. In tumors, the levels of TGF beta 1, IL-8, and IL-1 beta were higher than in normal counterparts (p < 0.001), and a positive correlation between IL-8 and IL-1 beta levels (p < 0.001) was found. TGF beta 1, IL-8, and IL-1 beta mRNA expression was examined in 12 tumors. TGF beta 1 mRNA was detected in all cases, IL-8 mRNA in 7, and IL-1 beta MRNA was undetectable. TGF beta 1, IL-8, and IL-1 beta immunoreactivity was then studied by immunohistochemistry. TGF beta 1 and IL-8 immunoreactivity was observed in neoplastic cells; IL-1 beta immunoreactivity was observed in mononuclear cells. In conclusion, in tumors IL-1 beta levels positively correlated with those of IL-8, and IL-1 beta as well as TGF beta 1 and IL-8 levels were significantly higher than in normal tissues.
引用
收藏
页码：968 / 973
页数：6
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