A cross-sectional analysis of candidate biomarkers of biological effect in smokers, never-smokers and ex-smokers

被引：24
作者：
Haswell, Linsey E. [1 ]
Papadopoulou, Ermioni [1 ]
Newland, Nik [1 ]
Shepperd, Christopher J. [1 ]
Lowe, Frazer J. [1 ]
机构：
[1] British Amer Tobacco Investments Ltd, Res & Dev Grp, Southampton SO15 8TL, Hants, England
来源：
BIOMARKERS | 2014年 / 19卷 / 05期
关键词：
Biomarkers; cancer; cardiovascular disease; COPD; inflammation; oxidative stress; smoking; toxicant; LOW-DENSITY-LIPOPROTEIN; MONOCYTE CHEMOATTRACTANT PROTEIN-1; INTERCELLULAR-ADHESION MOLECULE-1; CARDIOVASCULAR RISK-FACTORS; TOTAL ANTIOXIDANT CAPACITY; OXIDATIVE STRESS; CIGARETTE-SMOKING; LIPID-PEROXIDATION; ADULT SMOKERS; OXIDIZED LDL;
D O I：
10.3109/1354750X.2014.912354
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Context: Biomarkers of biological effect (BOBE) have been proposed as potential tools to assess tobacco product use, toxicity and disease risk. Objective: To determine if candidate BOBE can distinguish between smokers, never-smokers and former smokers. Methods: Biomarker levels were compared from 143 smokers, 61 never-smokers and 61 ex-smokers. Results: In total, 27 candidate biomarkers were assessed, 14 were significantly different between smokers and never-smokers (p<0.01) and of these 14 biomarkers, 12 were able to distinguish between smokers and former smokers (p<0.05), which indicates the potential for reversibility. Conclusions: A total of 12 of 27 BOBE are potentially useful tools for future product assessment.
引用
收藏
页码：356 / 367
页数：12
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