A cross-sectional analysis of candidate biomarkers of biological effect in smokers, never-smokers and ex-smokers

被引：24

作者：

Haswell, Linsey E. ^{[1
]}

Papadopoulou, Ermioni ^{[1
]}

Newland, Nik ^{[1
]}

Shepperd, Christopher J. ^{[1
]}

Lowe, Frazer J. ^{[1
]}

机构：

[1] British Amer Tobacco Investments Ltd, Res & Dev Grp, Southampton SO15 8TL, Hants, England

来源：

BIOMARKERS | 2014年 / 19卷 / 05期

关键词：

Biomarkers; cancer; cardiovascular disease; COPD; inflammation; oxidative stress; smoking; toxicant; LOW-DENSITY-LIPOPROTEIN; MONOCYTE CHEMOATTRACTANT PROTEIN-1; INTERCELLULAR-ADHESION MOLECULE-1; CARDIOVASCULAR RISK-FACTORS; TOTAL ANTIOXIDANT CAPACITY; OXIDATIVE STRESS; CIGARETTE-SMOKING; LIPID-PEROXIDATION; ADULT SMOKERS; OXIDIZED LDL;

D O I：

10.3109/1354750X.2014.912354

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Context: Biomarkers of biological effect (BOBE) have been proposed as potential tools to assess tobacco product use, toxicity and disease risk. Objective: To determine if candidate BOBE can distinguish between smokers, never-smokers and former smokers. Methods: Biomarker levels were compared from 143 smokers, 61 never-smokers and 61 ex-smokers. Results: In total, 27 candidate biomarkers were assessed, 14 were significantly different between smokers and never-smokers (p<0.01) and of these 14 biomarkers, 12 were able to distinguish between smokers and former smokers (p<0.05), which indicates the potential for reversibility. Conclusions: A total of 12 of 27 BOBE are potentially useful tools for future product assessment.

引用

页码：356 / 367

页数：12

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