ABO blood group and von Willebrand factor: biological implications

被引：46

作者：

Franchini, Massimo ^{[1
]}

Crestani, Silvia ^{[1
]}

Frattini, Francesco ^{[1
]}

Sissa, Cinzia ^{[1
]}

Bonfanti, Carlo ^{[1
]}

机构：

[1] Azienda Osped Carlo Poma, Dipartimento Med Trasfus & Ematol, Mantua, Italy

来源：

CLINICAL CHEMISTRY AND LABORATORY MEDICINE | 2014年 / 52卷 / 09期

关键词：

ABO; ADAMTS13; desmopressin; LRP1; von Willebrand disease; von Willebrand factor; N-LINKED GLYCOSYLATION; GENETIC RISK-FACTOR; FACTOR-VIII; ADAMTS13; PROTEOLYSIS; VASCULAR-DISEASE; HALF-LIFE; IN-VIVO; CLEARANCE; PHENOTYPE; COHORT;

D O I：

10.1515/cclm-2014-0564

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

ABO blood group antigens are complex carbohydrate molecules expressed on the surface of red blood cells and a variety of human cells and tissues. It is well known that ABO blood type exerts a profound influence on hemostasis, being a major determinant of von Willebrand factor (VWF), and consequently factor VIII, plasma levels. In this review, we will focus on the molecular mechanisms underlying the interaction between ABO blood group and VWF in normal and pathological conditions.

引用

页码：1273 / 1276

页数：4

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