Association of MTHFR C677T polymorphisms and colorectal cancer risk in Asians: evidence of 12,255 subjects

被引：15
|
作者：
Guo, X. -P. [1 ]
Wang, Y. [2 ]
Zhao, H. [1 ]
Song, S. -D. [1 ]
Zhou, J. [1 ]
Han, Y. [1 ]
机构：
[1] Soochow Univ, Dept Gen Surg, Affiliated Hosp 1, Suzhou 215006, Jiangsu, Peoples R China
[2] Soochow Univ, Dept Respirat, Affiliated Hosp 1, Suzhou 215006, Jiangsu, Peoples R China
来源：
CLINICAL & TRANSLATIONAL ONCOLOGY | 2014年 / 16卷 / 07期
关键词：
Colorectal cancer; MTHFR C677T; Polymorphism; Meta-analysis; METHYLENETETRAHYDROFOLATE-REDUCTASE C677T; GENETIC POLYMORPHISMS; COLON-CANCER; 5,10-METHYLENETETRAHYDROFOLATE REDUCTASE; FOLATE; SUSCEPTIBILITY; METAANALYSIS; METABOLISM; ALCOHOL; A1298C;
D O I：
10.1007/s12094-013-1126-x
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
To investigate the relationship of the MTHFR polymorphisms (C677T) and the risk of CRC by meta-analysis. Relevant literatures concerning the association between the MTHFR C677T polymorphism and the risk of CRC were searched using the electronic database PubMed, EMBASE, Cochrane and China National Knowledge Infrastructure (CNKI). Odds ratio (ORs) and 95 % confidence intervals (CIs) were determined to assess the gene-disease association using fixed or random effect models, according to the heterogeneity among included studies. The study shows that the MTHFR 677 TT homozygous genotype significantly decreases the risk of CRC in Asians (TT vs. CC: OR = 0.82, 95 % CI 0.73-0.92; TT vs. CT: OR = 0.84, 95 % CI 0.75-0.94; TT vs. CC+TT: OR = 0.83, 95 % CI 0.75-0.93). This meta-analysis indicated that the MTHFR 677 TT homozygous genotype decreased the risk of CRC in Asians, while the MTHFR 677 CT heterozygous genotype did not contribute to CRC susceptibility.
引用
收藏
页码：623 / 629
页数：7
相关论文
共 50 条
  • [1] Association of MTHFR C677T polymorphisms and colorectal cancer risk in Asians: evidence of 12,255 subjects
    X.-P. Guo
    Y. Wang
    H. Zhao
    S.-D. Song
    J. Zhou
    Y. Han
    Clinical and Translational Oncology, 2014, 16 : 623 - 629
  • [2] MTHFR C677T Polymorphism and Colorectal Cancer Risk in Asians, a Meta- analysis of 21 Studies
    Yang, Zhen
    Zhang, Xie-Fu
    Liu, Hong-Xiang
    Hao, Yong-Shun
    Zhao, Chun-Lin
    ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, 2012, 13 (04) : 1203 - 1208
  • [3] Quantitative assessment of the association between MTHFR C677T polymorphism and colorectal cancer risk in East Asians
    Zhong, Shan
    Yang, Jia-He
    Liu, Kai
    Jiao, B. H.
    Chang, Zhi-Jie
    TUMOR BIOLOGY, 2012, 33 (06) : 2041 - 2051
  • [4] MTHFR C677T polymorphism contributes to the risk for gastric cancer
    Yan, Shushan
    Xu, Donghua
    Wang, Pingping
    Wang, Ping
    Liu, Chengcheng
    Hua, Changjiang
    Jiang, Tao
    Zhang, Bin
    Li, Zengcai
    Lu, Lei
    Liu, Xianzhong
    Wang, Bingji
    Zhang, Donghua
    Zhang, Rongsheng
    He, Shaoheng
    Sun, Beicheng
    Wang, Xuan
    TUMOR BIOLOGY, 2014, 35 (03) : 2123 - 2132
  • [5] Association Between MTHFR Polymorphism (C677T) With Nonfamilial Colorectal Cancer
    Haghighi, Mahdi Montazer
    Radpour, Ramin
    Mahmoudi, Touraj
    Mohebbi, Seyed Reza
    Vahedi, Mohsen
    Zali, Mohammad Reza
    ONCOLOGY RESEARCH, 2009, 18 (2-3) : 57 - 63
  • [6] Polymorphisms of MTHFR C677T and A1298C Association With Oral Carcinoma Risk: A Meta-Analysis
    Zhuo, Xianlu
    Ling, Junjun
    Zhou, Yan
    Zhao, Houyu
    Song, Yufeng
    Tan, Yinghui
    CANCER INVESTIGATION, 2012, 30 (06) : 447 - 452
  • [7] Risk association of meningiomas with MTHFR C677T and GSTs polymorphisms: a meta-analysis
    Ding, Hao
    Liu, Wei
    Yu, Xinyuan
    Wang, Lei
    Shao, Lingmin
    Yi, Wei
    INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2014, 7 (11): : 3904 - 3914
  • [8] Lack of significant association between MTHFR gene C677T polymorphism and colorectal cancer in the Azerbaijani population
    Aslanov, H.
    Agaev, R.
    Bayramov, B.
    Hadizade, A.
    Alakbarova, N.
    Abdulrahimli, S.
    Yagublu, V
    GENETICS AND MOLECULAR RESEARCH, 2023, 22 (01):
  • [9] Meta Analysis of Methylenetetrahydrofolate Reductase (MTHFR) C677T polymorphism and its association with folate and colorectal cancer
    Ye, Meng
    Xu, Guojie
    Zhang, Liming
    Kong, Zhihui
    Qiu, Zhenhua
    BMC CANCER, 2025, 25 (01)
  • [10] Association of methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and the risk of sporadic colorectal cancer
    Baghad, Imane
    Erreguibi, Driss
    Boufettal, Rachid
    Eljai, Saad Rifki
    Chihab, Farid
    Nadifi, Sellama
    PAN AFRICAN MEDICAL JOURNAL, 2021, 38
12345