The Role of Ribonuclease 1 and Ribonuclease Inhibitor 1 in Acute Kidney Injury after Open and Endovascular Thoracoabdominal Aortic Aneurysm Repair

被引:6
|
作者
Zechendorf, Elisabeth [1 ]
Gombert, Alexander [2 ]
Bulow, Tanja [3 ]
Frank, Nadine [1 ]
Beckers, Christian [1 ]
Peine, Arne [1 ]
Kotelis, Drosos [2 ]
Jacobs, Michael J. [2 ]
Marx, Gernot [1 ]
Martin, Lukas [1 ]
机构
[1] Univ Hosp RWTH Aachen, Dept Intens Care & Intermediate Care, D-52062 Aachen, Germany
[2] Univ Hosp RWTH Aachen, European Vasc Ctr Aachen Maastricht, D-52062 Aachen, Germany
[3] Univ Hosp RWTH Aachen, Dept Med Stat, D-52062 Aachen, Germany
关键词
thoracoabdominal aortic aneurysm; ribonuclease; ribonuclease inhibitor 1; biomarker; complex aortic surgery; acute kidney injury; ACUTE-RENAL-FAILURE; RNASE INHIBITOR; OUTCOMES;
D O I
10.3390/jcm9103292
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Acute kidney injury (AKI) is one of the most common post-operative complications and is closely associated with increased mortality after open and endovascular thoracoabdominal aortic aneurysm (TAAA) repair. Ribonuclease (RNase) 1 belongs to the group of antimicrobial peptides elevated in septic patients and indicates the prediction of two or more organ failures. The role of RNase 1 and its antagonist RNase inhibitor 1 (RNH1) after TAAA repair is unknown. In this study, we analyzed RNase 1 and RNH1 serum levels in patients undergoing open (n = 14) or endovascular (n = 19) TAAA repair to determine their association with post-operative AKI and in-hospital mortality. Increased RNH1 serum levels after open TAAA repair as compared with endovascular TAAA repair immediately after surgery and 12, 48, and 72 h after surgery (all p < 0.05) were observed. Additionally, elevated RNase 1 and RNH1 serum levels 12, 24, and 48 h after surgery were shown to be significantly associated with AKI (all p < 0.05). RNH1 serum levels before and RNase 1 serum levels 12 h after TAAA repair were significantly correlated with in-hospital mortality (both p < 0.05). On the basis of these findings, RNase 1 and RNH1 may be therapeutically relevant and may represent biomarkers for post-operative AKI and in-hospital mortality.
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页码:1 / 13
页数:13
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