Novel 19F MRS/I Nanoprobe Based on pH-Responsive PEGylated Nanogel: pH-Dependent 19F Magnetic Resonance Studies

被引：21

作者：

Oishi, Motoi ^{[2
,3
,4
]}

Sumitani, Shogo ^{[2
]}

Bronich, Tatiana K. ^{[1
,7
,8
]}

Kabanov, Alexander V. ^{[1
,7
,8
]}

Boska, Michael D. ^{[7
,8
,9
,10
]}

Nagasaki, Yukio ^{[2
,3
,4
,5
,6
]}

机构：

[1] Univ Nebraska Med Ctr, Dept Pharmaceut Sci, Omaha, NE 68198 USA

[2] Univ Tsukuba, Grad Sch Pure & Appl Sci, Tsukuba, Ibaraki 3058573, Japan

[3] Univ Tsukuba, Tsukuba Res Ctr Interdisciplinary Mat Sci, Tsukuba, Ibaraki 3058573, Japan

[4] Univ Tsukuba, Ctr Tsukuba Adv Res Alliance, Tsukuba, Ibaraki 3058573, Japan

[5] Univ Tsukuba, Masters Sch Med Sci, Tsukuba, Ibaraki 3058573, Japan

[6] Natl Inst Mat Sci, Int Ctr Mat Nanoarchitecton Satellite, Tsukuba, Ibaraki 3058573, Japan

[7] Univ Nebraska Med Ctr, Ctr Drug Delivery, Omaha, NE 68198 USA

[8] Univ Nebraska Med Ctr, Ctr Nanomed, Omaha, NE 68198 USA

[9] Univ Nebraska Med Ctr, Dept Radiol, Omaha, NE 68198 USA

[10] Univ Nebraska Med Ctr, Ctr Neurovirol & Neurodegenerat Disorders, Omaha, NE 68198 USA

来源：

CHEMISTRY LETTERS | 2009年 / 38卷 / 02期

关键词：

PEG TETHERED CHAINS; ON-OFF REGULATION; ANTICANCER DRUGS; NANOPARTICLES; DELIVERY; TUMOR; CHEMOTHERAPY; COPOLYMER; MICELLES; CANCER;

D O I：

10.1246/cl.2009.128

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The pH-responsive PEGylated nanogels composed of the cross-linked poly [2-(N,N-diethylamino)ethyl methacrylate]-copoly(2,2,2-trifluoroethyl methacrylate) gel core showed a remarkable on-off regulation of F-19 magnetic resonance signal intensity (7, values) as well as signal-to-noise ratios in response to extracellular pH 6.5 Of tumor environment under F-19 magnetic resonance spectroscopic imaging (MRS/I), demonstrating the utility of the PEGylated nanogels as solid tumor-specific F-19 MRI/S nanoprobes.

引用

页码：128 / 129

页数：2

共 18 条

[1] Polymer micelles with cross-linked ionic cores for delivery of anticancer drugs [J].

Bontha, Satya ;

Kabanov, Alexander V. ;

Bronich, Tatiana K. .

JOURNAL OF CONTROLLED RELEASE, 2006, 114 (02) :163-174

[2] Unusual aggregation behavior of a novel tertiary amine methacrylate-based diblock copolymer: Formation of micelles and reverse micelles in aqueous solution [J].

Butun, V ;

Billingham, NC ;

Armes, SP .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1998, 120 (45) :11818-11819

[3] DRUG POLYMER CONJUGATES - POTENTIAL FOR IMPROVED CHEMOTHERAPY [J].

DUNCAN, R .

ANTI-CANCER DRUGS, 1992, 3 (03) :175-210

[4]

Gerweck LE, 1996, CANCER RES, V56, P1194

[5] The endocytic pathway: A mosaic of domains [J].

Gruenberg, J .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2001, 2 (10) :721-730

[6] pH-sensitive nanogel possessing reactive PEG tethered chains on the surface [J].

Hayashi, H ;

Iijima, M ;

Kataoka, K ;

Nagasaki, Y .

MACROMOLECULES, 2004, 37 (14) :5389-5396

[7] Block and graft copolymers and Nanogel™ copolymer networks for DNA delivery into cell [J].

Lemieux, P ;

Vinogradov, SV ;

Gebhart, CL ;

Guérin, N ;

Paradis, G ;

Nguyen, HK ;

Ochietti, B ;

Suzdaltseva, YG ;

Bartakova, EV ;

Bronich, TK ;

St-Pierre, Y ;

Alakhov, VY ;

Kabanov, AV .

JOURNAL OF DRUG TARGETING, 2000, 8 (02) :91-105

[8]

MATSUMURA Y, 1986, CANCER RES, V46, P6387

[9] Endocytosis [J].

Mukherjee, S ;

Ghosh, RN ;

Maxfield, FR .

PHYSIOLOGICAL REVIEWS, 1997, 77 (03) :759-803

[10] Synthesis, characterization, and biomedical applications of core-shell-type stimuli-responsive nanogels -: Nanogel composed of poly[2-(N,N-diethylamino)ethyl methacrylate] core and PEG tethered chains [J].

Oishi, Motoi ;

Nagasaki, Yukio .

REACTIVE & FUNCTIONAL POLYMERS, 2007, 67 (11) :1311-1329

← 1 2 →