COVID-19 in the elderly people and advances in vaccination approaches

被引：38

作者：

Dhama, Kuldeep ^{[1
]}

Patel, Shailesh Kumar ^{[1
]}

Natesan, Senthilkumar ^{[2
]}

Vora, Kranti Suresh ^{[2
,3
]}

Yatoo, Mohd Iqbal ^{[4
]}

Tiwari, Ruchi ^{[5
]}

Saxena, Shailendra K. ^{[6
]}

Singh, Karam Pal ^{[1
]}

Singh, Rajendra ^{[1
]}

Malik, Yashpal Singh ^{[7
]}

机构：

[1] ICAR Indian Vet Res Inst, Div Pathol, Bareilly 243122, Uttar Pradesh, India

[2] Indian Inst Publ Hlth Gandhinagar, Dept Infect Dis, Ganghinagar, Gujarat, India

[3] Univ Canberra, Hlth Res Inst, Canberra, ACT, Australia

[4] Sher E Kashmir Univ Agr Sci & Technol Kashmir, Fac Vet Sci & Anim Husb, Div Vet Clin Complex, Srinagar, Jammu & Kashmir, India

[5] Uttar Pradesh Pandit Deen Dayal Upadhyaya Pashu C, Dept Vet Microbiol & Immunol, Coll Vet Sci, Mathura, India

[6] King Georges Med Univ KGMU, Fac Med, Ctr Adv Res CFAR, Lucknow, Uttar Pradesh, India

[7] ICAR Indian Vet Res Inst, Div Biol Standardizat, Bareilly 243122, Uttar Pradesh, India

来源：

HUMAN VACCINES & IMMUNOTHERAPEUTICS | 2020年 / 16卷 / 12期

关键词：

SARS-CoV-2; covid-19; elderly people; vaccine;

D O I：

10.1080/21645515.2020.1842683

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The rapid worldwide spread of the COVID-19 pandemic, caused by the newly emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in tens of millions of infections and over one million deaths. SARS-CoV-2 infection affects all age groups; however, those over 60 years old are affected more severely. Moreover, pre-existing co-morbidities result in higher COVID-19-associated mortality in the geriatric population. This article highlights the associated risk factors of SARS-CoV-2 infection in older people and progress in developing COVID-19 vaccines, especially for efficient vaccination of the older population. There is also a summary of immunomodulatory and immunotherapeutic approaches to ameliorate the outcome of COVID-19 in older individuals.

引用

页码：2938 / 2943

页数：6

共 82 条

[1] Immunomodulatory therapy for the management of severe COVID-19. Beyond the anti-viral therapy: A comprehensive review [J].

Alijotas-Reig, Jaume ;

Esteve-Valverde, Enrique ;

Belizna, Cristina ;

Selva-O'Callaghan, Albert ;

Pardos-Gea, Josep ;

Quintana, Angela ;

Mekinian, Arsene ;

Anunciacion-Llunell, Ariadna ;

Miro-Mur, Francesc .

AUTOIMMUNITY REVIEWS, 2020, 19 (07)

[2] Imiquimod - A toll like receptor 7 agonist - Is an ideal option for management of COVID 19 [J].

Angelopoulou, Athina ;

Alexandris, Nikos ;

Konstantinou, Evangelia ;

Mesiakaris, Konstantinos ;

Zanidis, Charilaos ;

Farsalinos, Konstantinos ;

Poulas, Konstantinos .

ENVIRONMENTAL RESEARCH, 2020, 188

[3]

[Anonymous], 2020, PREVENTING MANAGING

[4] Potential of heparin and nafamostat combination therapy for COVID-19 [J].

Asakura, Hidesaku ;

Ogawa, Haruhiko .

JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2020, 18 (06) :1521-1522

[5] Chimeric Antigen Receptor T Cell Therapy During the COVID-19 Pandemic [J].

Bachanova, Veronika ;

Bishop, Michael R. ;

Dahi, Parastoo ;

Dholaria, Bhagirathbhai ;

Grupp, Stephan A. ;

Hayes-Lattin, Brandon ;

Janakiram, Murali ;

Maziarz, Richard T. ;

McGuirk, Joseph P. ;

Nastoupil, Loretta J. ;

Oluwole, Olalekan O. ;

Perales, Miguel-Angel ;

Porter, David L. ;

Riedell, Peter A. .

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2020, 26 (07) :1239-1246

[6] Pulmonary intravascular coagulation in COVID-19: possible pathogenesis and recommendations on anticoagulant/thrombolytic therapy [J].

Belen-Apak, F. Burcu ;

Sarialioglu, F. .

JOURNAL OF THROMBOSIS AND THROMBOLYSIS, 2020, 50 (02) :278-280

[7] Deployment of convalescent plasma for the prevention and treatment of COVID-19 [J].

Bloch, Evan M. ;

Shoham, Shmuel ;

Casadevall, Arturo ;

Sachals, Bruce S. ;

Shaz, Beth ;

Winters, Jeffrey L. ;

van Buskirk, Camille ;

Grossman, Brenda J. ;

Joyner, Michael ;

Henderson, Jeffrey P. ;

Pekosz, Andrew ;

Lau, Bryan ;

Wesolowski, Amy ;

Katz, Louis ;

Shan, Hua ;

Auwaerter, Paul G. ;

Thomas, David ;

Sullivan, David J. ;

Paneth, Nigel ;

Gehrie, Eric ;

Spitalnik, Steven ;

Hod, Eldad A. ;

Pollack, Lewis ;

Nicholson, Wayne T. ;

Pirofski, Liise-Anne ;

Bailey, Jeffrey A. ;

Tobian, Aaron A. R. .

JOURNAL OF CLINICAL INVESTIGATION, 2020, 130 (06) :2757-2765

[8]

Bonanad C, 2020, REV ESP CARDIOL, V73, P569, DOI [10.1016/j.rec.2020.05.001, 10.1016/j.recesp.2020.03.027]

[9] The key role of zinc in elderly immunity: A possible approach in the COVID-19 crisis [J].

Brasiel, Poliana Guiomar de Almeida .

CLINICAL NUTRITION ESPEN, 2020, 38 :65-66

[10] Immunomodulatory Drugs in the Management of SARS-CoV-2 [J].

Burrage, Daniel R. ;

Koushesh, Soraya ;

Sofat, Nidhi .

FRONTIERS IN IMMUNOLOGY, 2020, 11

← 1 2 3 4 5 6 7 8 9 →