Enhanced expansion and tumor targeting of adoptively transferred T cells with NKTR-214

被引：0
|
作者：
Parisi, Giulia [1 ]
Saco, Justin [1 ]
Bergara, Felix [1 ]
Krystofinski, Paige [1 ]
Zhang, Ruixue [1 ]
Saus, Cristina Puig [1 ]
Hu-Lieskovan, Siwen [1 ]
Comin-Anduix, Begonya [1 ]
Wu, Anna [1 ]
Charych, Deborah H. [2 ]
Ribas, Antoni [1 ]
机构：
[1] Univ Calif Los Angeles, Los Angeles, CA USA
[2] Nektar Therapeut, San Francisco, CA USA
来源：
CANCER RESEARCH | 2018年 / 78卷 / 13期
关键词：
D O I：
10.1158/1538-7445.AM2018-3566
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
3566
引用
收藏
页数：2
相关论文
共 50 条
  • [1] NKTR-214 synergizes with radiotherapy to drive tumor regression
    Mcnamara, Michael J.
    Kasiewicz, Melissa
    Hilgart-Martiszus, Ian
    Hoch, Ute
    Charych, Deborah H.
    Redmond, William L.
    CANCER RESEARCH, 2017, 77
  • [2] Immune memory in nonclinical models after treatment with NKTR-214, an engineered cytokine biased towards expansion of CD8+T cells in tumor.
    Charych, Deborah H.
    Rubas, Werner
    Dixi, Vidula
    Cetz, Janet
    Pena, Rhoneil
    Langowski, John L.
    Hoch, Ute
    Addepalli, Murali
    Doberstein, Stephen K.
    Zalevsky, Jonathan
    JOURNAL OF CLINICAL ONCOLOGY, 2016, 34 (15)
  • [3] Permissive expansion and homing of adoptively transferred T cells in tumor-bearing hosts
    Perez, C.
    Jukica, A.
    Listopad, J. J.
    Anders, K.
    Kuehl, A. A.
    Loddenkemper, C.
    Blankenstein, T.
    Charo, J.
    INTERNATIONAL JOURNAL OF CANCER, 2015, 137 (02) : 359 - 371
  • [4] Treatment of subcutaneous tumor with adoptively transferred T cells
    Peng, LM
    Shu, SY
    Krauss, JC
    CELLULAR IMMUNOLOGY, 1997, 178 (01) : 24 - 32
  • [5] Combination of NKTR-214 and radiotherapy (RT) to reverse anergy and expand tumor-specific CD8 T Cells
    Walker, Joshua
    Kasiewicz, Melissa
    McNamara, Michael
    Hilgart-Martiszus, Ian
    Hock, Ute
    Charych, Deborah
    Redmond, William
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2017, 5
  • [6] Longitudinal and quantitative imaging of the localization, expansion, and contraction of tumor targeted adoptively transferred T cells
    Vedvyas, Yogindra
    Shevlin, Enda
    Zaman, Marjan
    Min, Irene M.
    Jin, Moonsoo M.
    CANCER RESEARCH, 2017, 77
  • [7] NKTR-214 enhances anti-tumor T cell immune responses induced by checkpoint blockade or vaccination
    Sharma, Meenu
    Fa'ak, Faisal
    Janssen, Louise
    Khong, Hiep
    Xiao, Zhilan
    Hailemichael, Yared
    Singh, Manisha
    Vianden, Christina
    Diab, Adi
    Zalevsky, Jonathan
    Hoch, Ute
    Overwijk, Willem
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2017, 5
  • [8] Targeting STAT3 in Adoptively Transferred T Cells Promotes Their In Vivo Expansion and Antitumor Effects
    Kujawski, Maciej
    Zhang, Chunyan
    Herrmann, Andreas
    Reckamp, Karen
    Scuto, Anna
    Jensen, Michael
    Deng, Jiehui
    Forman, Stephen
    Figlin, Robert
    Yu, Hua
    CANCER RESEARCH, 2010, 70 (23) : 9599 - 9610
  • [9] B cells imprint adoptively transferred CD8+ T cells with enhanced tumor immunity
    Smith, Aubrey S.
    Knochelmann, Hannah M.
    Wyatt, Megan M.
    Rivera, Guillermo O. Rangel
    Rivera-Reyes, Amalia M.
    Dwyer, Connor J.
    Ware, Michael B.
    Cole, Anna C.
    Neskey, David M.
    Rubinstein, Mark P.
    Liu, Bei
    Thaxton, Jessica E.
    Bartee, Eric
    Paulos, Chrystal M.
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2022, 10 (01)
  • [10] Baseline tumor-immune signatures associated with response to bempegaldesleukin (NKTR-214) and nivolumab.
    Hurwitz, Michael E.
    Cho, Daniel C.
    Balar, Arjun Vasant
    Curti, Brendan D.
    Siefker-Radtke, Arlene O.
    Sznol, Mario
    Kluger, Harriet M.
    Bernatchez, Chantale
    Fanton, Christie
    Iacucci, Ernesto
    Liu, Yi
    Tuan Nguyen
    Overwijk, Willem
    Zalevsky, Jonathan
    Tagliaferri, Mary Ann
    Hoch, Ute
    Diab, Adi
    JOURNAL OF CLINICAL ONCOLOGY, 2019, 37 (15)
12345