Synthesis and Antitumor Evaluation of 3-epi-Jaspine B Analogues

被引：2

作者：

Zhang En ^{[1
]}

Wang Shang ^{[1
]}

Jiao Weiwei ^{[1
]}

Wang Mingming ^{[1
]}

Yue Jingfei ^{[1
]}

Xu Shuaimin ^{[1
]}

Wang Ya'na ^{[1
]}

Ambrosi, Horst-Dieter ^{[2
]}

Liu Hongmin ^{[1
]}

机构：

[1] Zhengzhou Univ, Sch Pharmaceut Sci, Collaborat Innovat Ctr New Drug Res & Wily Evalua, Zhengzhou 450001, Peoples R China

[2] AnalytiCon Discovery GmbH, Hermannswerder Haus 17, D-14473 Potsdam, Germany

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2017年 / 37卷 / 01期

基金：

中国国家自然科学基金;

关键词：

3-epi-jaspine B; antitumor; hydrogen sulfide; analogue; PACHASTRISSAMINE JASPINE B; BIOLOGICAL EVALUATION; MARINE SPONGE; DERIVATIVES; INHIBITORS; EFFICIENT; DESIGN;

D O I：

10.6023/cjoc201607028

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Jaspine B is a natural product with significant antitumor activity, which was isolated from the marine sponge Pachastrissa sp. In order to find new antitumor compounds with high efficiency and succinct synthetic methods, a series of 3-epi-jaspine B analogues were designed and synthesized. 16 compounds were synthesized and all of them were unknown in the literature. Their structures were determined by H-1 NMR, C-13 NMR and HRMS. The antitumor activity of these compounds against four tumor cell lines B16 -F10, A-549, MCF-7 and PC -3 was assayed using thiazolyl blue (MTT) assay, and some compounds showed potent inhibitory effect on tumor cells. Compounds 8f and 11 were more potent against A-549 with IC50 of (9.646 +/- 0.984) and (7.144 +/- 0.854) mu g/mL.

引用

页码：141 / 148

页数：8

共 25 条

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