Facile preparation of shell crosslinked micelles for redox-responsive anticancer drug release

被引：33

作者：

Gao, Lilong ^{[1
]}

Luo, Qiaojie ^{[2
]}

Wang, Ying ^{[1
]}

Du, Hong ^{[1
]}

Li, Xiaodong ^{[2
]}

Shen, Zhiquan ^{[1
]}

Zhu, Weipu ^{[1
]}

机构：

[1] Zhejiang Univ, MOE Key Lab Macromol Synth & Functionalizat, Dept Polymer Sci & Engn, Hangzhou 310027, Peoples R China

[2] Zhejiang Univ, Dept Oral & Maxillofacial Surg, Affiliated Stomatol Hosp, Sch Med, Hangzhou 310006, Zhejiang, Peoples R China

来源：

RSC ADVANCES | 2014年 / 4卷 / 08期

基金：

中国国家自然科学基金;

关键词：

RING-OPENING POLYMERIZATION; DEHYDRATION POLYCONDENSATIONS; TEMPERATURE POLYCONDENSATION; POLY(ETHYLENE GLYCOL); EPSILON-CAPROLACTONE; DICARBOXYLIC-ACIDS; ROOM-TEMPERATURE; HYDROXYL-GROUPS; DELIVERY; POLY(EPSILON-CAPROLACTONE);

D O I：

10.1039/c3ra41926f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We report a "one-pot" method to synthesize an amphiphilic triblock copolymer with multiple pendant mercapto groups in the hydrophilic block. Shell crosslinked micelles were prepared in a facile manner via the self-assembly of this copolymer in aqueous solution and cross-linking of the micellar shell by H2O2. These shell crosslinked micelles show rapid bioreductive responsiveness for anticancer drug release.

引用

页码：4177 / 4180

页数：4

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