Facile preparation of shell crosslinked micelles for redox-responsive anticancer drug release

被引：33
|
作者：
Gao, Lilong [1 ]
Luo, Qiaojie [2 ]
Wang, Ying [1 ]
Du, Hong [1 ]
Li, Xiaodong [2 ]
Shen, Zhiquan [1 ]
Zhu, Weipu [1 ]
机构：
[1] Zhejiang Univ, MOE Key Lab Macromol Synth & Functionalizat, Dept Polymer Sci & Engn, Hangzhou 310027, Peoples R China
[2] Zhejiang Univ, Dept Oral & Maxillofacial Surg, Affiliated Stomatol Hosp, Sch Med, Hangzhou 310006, Zhejiang, Peoples R China
来源：
RSC ADVANCES | 2014年 / 4卷 / 08期
基金：
中国国家自然科学基金;
关键词：
RING-OPENING POLYMERIZATION; DEHYDRATION POLYCONDENSATIONS; TEMPERATURE POLYCONDENSATION; POLY(ETHYLENE GLYCOL); EPSILON-CAPROLACTONE; DICARBOXYLIC-ACIDS; ROOM-TEMPERATURE; HYDROXYL-GROUPS; DELIVERY; POLY(EPSILON-CAPROLACTONE);
D O I：
10.1039/c3ra41926f
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We report a "one-pot" method to synthesize an amphiphilic triblock copolymer with multiple pendant mercapto groups in the hydrophilic block. Shell crosslinked micelles were prepared in a facile manner via the self-assembly of this copolymer in aqueous solution and cross-linking of the micellar shell by H2O2. These shell crosslinked micelles show rapid bioreductive responsiveness for anticancer drug release.
引用
收藏
页码：4177 / 4180
页数：4
相关论文
共 50 条
  • [21] Redox-Responsive Supramolecular Micelles for Targeted Imaging and Drug Delivery to Tumor
    Liu, Tao
    Liu, Zhongning
    Chen, Jiachen
    Jin, Ronghua
    Bai, Yongkang
    Zhou, Yongsheng
    Chen, Xin
    JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, 2018, 14 (06) : 1107 - 1116
  • [22] Facile Construction of pH- and Redox-Responsive Micelles from a Biodegradable Poly(β-hydroxyl amine) for Drug Delivery
    Li, Dawei
    Bu, Yazhong
    Zhang, Lining
    Wang, Xing
    Yang, Yanyu
    Zhuang, Yaping
    Yang, Fei
    Shen, Hong
    Wu, Decheng
    BIOMACROMOLECULES, 2016, 17 (01) : 291 - 300
  • [23] Redox and pH-responsive degradable micelles for dually activated intracellular anticancer drug release
    Chen, Wei
    Zhong, Ping
    Meng, Fenghua
    Cheng, Ru
    Deng, Chao
    Feijen, Jan
    Zhong, Zhiyuan
    JOURNAL OF CONTROLLED RELEASE, 2013, 169 (03) : 171 - 179
  • [24] Facile preparation of redox-responsive hollow mesoporous silica spheres for the encapsulation and controlled release of corrosion inhibitors
    Sun Shuangqing
    Zhao Xiyu
    Cheng Meng
    Wang Yan
    Li Chunling
    Hu Songqing
    PROGRESS IN ORGANIC COATINGS, 2019, 136
  • [25] Redox-Responsive Drug Delivery
    Gauthier, Marc A.
    ANTIOXIDANTS & REDOX SIGNALING, 2014, 21 (05) : 705 - 706
  • [26] Redox-responsive polyanhydride micelles for cancer therapy
    Wang, Jie
    Yang, Guang
    Guo, Xing
    Tang, Zhaomin
    Zhong, Zhendong
    Zhou, Shaobing
    BIOMATERIALS, 2014, 35 (09) : 3080 - 3090
  • [27] Redox-responsive PAEFc-b-PDMAEMA amphiphilic block copolymer self-assembly micelles: Physicochemical properties and anticancer drug controlled release
    Wang, Yuan
    Luo, Yan-Ling
    Xu, Feng
    Chen, Ya-Shao
    Tang, Wei
    JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, 2017, 48 : 66 - 78
  • [28] Redox-responsive core-crosslinking micelles capable of on-demand, concurrent drug release and structure disassembly
    Wang, Hua
    Cheng, Jianjun
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2013, 246
  • [29] Redox-responsive micelles for triggered drug delivery and effective laryngopharyngeal cancer therapy
    Sun, Changling
    Li, Xiaoying
    Du, Xiaodong
    Wang, Teng
    INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2018, 112 : 65 - 73
  • [30] Novel Redox-Responsive Amphiphilic Copolymer Micelles for Drug Delivery: Synthesis and Characterization
    Bae, Jungeun
    Maurya, Abhijeet
    Shariat-Madar, Zia
    Murthy, S. Narasimha
    Jo, Seongbong
    AAPS JOURNAL, 2015, 17 (06): : 1357 - 1368
12345