Facile preparation of shell crosslinked micelles for redox-responsive anticancer drug release

被引：33
作者：
Gao, Lilong [1 ]
Luo, Qiaojie [2 ]
Wang, Ying [1 ]
Du, Hong [1 ]
Li, Xiaodong [2 ]
Shen, Zhiquan [1 ]
Zhu, Weipu [1 ]
机构：
[1] Zhejiang Univ, MOE Key Lab Macromol Synth & Functionalizat, Dept Polymer Sci & Engn, Hangzhou 310027, Peoples R China
[2] Zhejiang Univ, Dept Oral & Maxillofacial Surg, Affiliated Stomatol Hosp, Sch Med, Hangzhou 310006, Zhejiang, Peoples R China
来源：
RSC ADVANCES | 2014年 / 4卷 / 08期
基金：
中国国家自然科学基金;
关键词：
RING-OPENING POLYMERIZATION; DEHYDRATION POLYCONDENSATIONS; TEMPERATURE POLYCONDENSATION; POLY(ETHYLENE GLYCOL); EPSILON-CAPROLACTONE; DICARBOXYLIC-ACIDS; ROOM-TEMPERATURE; HYDROXYL-GROUPS; DELIVERY; POLY(EPSILON-CAPROLACTONE);
D O I：
10.1039/c3ra41926f
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We report a "one-pot" method to synthesize an amphiphilic triblock copolymer with multiple pendant mercapto groups in the hydrophilic block. Shell crosslinked micelles were prepared in a facile manner via the self-assembly of this copolymer in aqueous solution and cross-linking of the micellar shell by H2O2. These shell crosslinked micelles show rapid bioreductive responsiveness for anticancer drug release.
引用
收藏
页码：4177 / 4180
页数：4
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