Efficient One-Pot Synthesis of 3,5-Disubstituted 1,3,4-Thiadiazole from Dithioesters under Mild Condition

被引：6
|
作者：
Kemparajegowda [1 ]
Swarup, Hassan A. [1 ]
Sandhya, Nagarakere C. [2 ]
Rangappa, Shobith [3 ]
Mantelingu, Kempegowda [1 ]
Rangappa, Kanchugarakoppal S. [4 ]
机构：
[1] Univ Mysore, Dept Studies Chem, Mysuru 570006, India
[2] St Philomenas Coll, PG Dept Chem, Mysuru 570006, Karnataka, India
[3] Adichunchanagiri Canc Res Ctr, Mandya, Karnataka, India
[4] Univ Mysore, Inst Excellence, Mysore 570006, Karnataka, India
来源：
CHEMISTRYSELECT | 2019年 / 4卷 / 15期
关键词：
Benzothiohydrazide; 3; 5-Disubstituted; 1; 4-thiadiazole; Dithioesters; Hydrazine hydrate; Triethyl amine; C-H ARYLATION; TANDEM APPROACH; ANTICANCER EVALUATION; DERIVATIVES; CYCLOCONDENSATION; CONSTRUCTION;
D O I：
10.1002/slct.201900630
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An efficient synthetic approach for the construction of 3,5-disubstituted 1,3,4-thiadiazoles from dithioesters, hydrazine hydrate and triethyl amine has been developed under transition-metal free condition. This methodology efficiently constructs 3,5-disubstituted 1,3,4-thiadiazole in good to excellent yields with the advantages of wide functional group tolerance and operational simplicity.
引用
收藏
页码：4611 / 4614
页数：4
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