New Prenylxanthones from the Deep-Sea Derived Fungus Emericella sp SCSIO 05240

被引：40

作者：

Fredimoses, Mangaladoss ^{[1
]}

Zhou, Xuefeng ^{[1
]}

Lin, Xiuping ^{[1
]}

Tian, Xinpeng ^{[1
]}

Ai, Wen ^{[1
]}

Wang, Junfeng ^{[1
]}

Liao, Shengrong ^{[1
]}

Liu, Juan ^{[1
]}

Yang, Bin ^{[1
]}

Yang, Xianwen ^{[1
]}

Liu, Yonghong ^{[1
]}

机构：

[1] Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Trop Marine Bioresources & Ecol, Guangdong Key Lab Marine Mat Med,RNAM Ctr Marine, Guangzhou 510301, Guangdong, Peoples R China

来源：

MARINE DRUGS | 2014年 / 12卷 / 06期

基金：

国家高技术研究发展计划(863计划); 中国国家自然科学基金;

关键词：

prenylxanthone; Emericella; deep-sea; fungus; PRENYLATED XANTHONES; VARIECOLOR; METABOLITES; INSIGHTS;

D O I：

10.3390/md12063190

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Four new prenylxanthones, emerixanthones A-D (1-4), together with six known analogues (5-10), were isolated from the culture of the deep-sea sediment derived fungus Emericella sp. SCSIO 05240, which was identified on the basis of morphology and ITS sequence analysis. The newstructures were determined by NMR (H-1, C-13 NMR, HSQC, HMBC, and H-1-H-1 COSY), MS, CD, and optical rotation analysis. The absolute configuration of prenylxanthone skeleton was also confirmed by the X-ray crystallographic analysis. Compounds 1and 3 showed weak antibacterial activities, and 4 displayed mild antifungal activities against agricultural pathogens.

引用

页码：3190 / 3202

页数：13

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