Vitamin D and brain volumetric changes: Systematic review and meta-analysis

被引:46
作者
Annweiler, Cedric [1 ,2 ,3 ]
Annweiler, Thierry [4 ]
Montero-Odasso, Manuel [5 ]
Bartha, Robert [3 ]
Beauchet, Olivier [1 ,2 ,6 ]
机构
[1] Univ Angers, Angers Univ Hosp, UNAM, Dept Neurosci,Div Geriatr Med,UPRES EA 4638, Angers, France
[2] Univ Angers, Angers Univ Hosp, UNAM, Memory Clin,UPRES EA 4638, Angers, France
[3] Univ Western Ontario, Schulich Sch Med & Dent, Robarts Res Inst, Dept Med Biophys, London, ON, Canada
[4] Univ Hosp St Etienne, Dept Radiol, St Etienne, France
[5] Univ Western Ontario, Parkwood Hosp, Lawson Hlth Res Inst, Gait & Brain Lab, London, ON, Canada
[6] Biomathics, Paris, France
关键词
Brain; Neuroimaging; Magnetic resonance imaging; Meta-analysis; Neuroendocrinology; Vitamin D; 25-HYDROXYVITAMIN D CONCENTRATIONS; NUTRIENT BIOMARKER PATTERNS; NERVE GROWTH-FACTOR; D SUPPLEMENTATION; MRI MEASURES; 1,25-DIHYDROXYVITAMIN D-3; ALZHEIMERS-DISEASE; COGNITIVE FUNCTION; EFFECT SIZE; ASSOCIATION;
D O I
10.1016/j.maturitas.2014.02.013
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Vitamin D has multiple functions in the nervous system. Our objective was to systematically review and quantitatively synthesize evidence on the location and nature of brain morphometric changes linked to vitamin D depletion or repletion. A Medline search was conducted in February 2014, without limit of date and language restriction, using the MeSH terms "Vitamin D" OR "Ergocalciferols" combined with "Brain Mapping" OR "Magnetic Resonance Imaging" OR "Tomography, X-ray Computed" OR "Tomography, Emission-Computed, Single-Photon" OR "Positron-Emission Tomography" OR "Nuclear Medicine" OR "Radionucleide Imaging". Of the 376 selected studies, nine observational studies two animal and seven human studies met the selection criteria. The number of participants ranged from 20 to 333 (40-79% female). Three studies were eligible for fixed-effects meta-analysis of bias-corrected effect size of the difference in lateral ventricle volume between cases with vitamin D depletion and controls. Results showed that vitamin D depletion was associated with lower brain volume, specifically larger lateral ventricles. The pooled effect size was 1.01 [95% CI: 0.62; 1.41], a 'large' effect size indicating that the ventricle volume was 1.01 SD higher with vitamin D depletion. Results on brain subvolumes were mixed, and indicated that brain atrophy with vitamin D depletion could be explained not by temporal lobe atrophy but rather by loss of matter at the cranial vertex, possibly in the precuneus cortex. In conclusion, despite increasing evidence arguing for an action of vitamin D in the brain, data is sparse regarding brain morphological changes related to vitamin D depletion. The retrieved association between vitamin D depletion and brain atrophy provides a scientific base for vitamin D replacement trials. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:30 / 39
页数:10
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