Immature Platelet Fraction as a Biomarker for Disease Severity in Pediatric Respiratory Coronavirus Disease 2019

被引：5

作者：

Lee, Nicholas C. J. ^{[1
,2
]}

Demir, Yusuf Kemal ^{[3
]}

Ashraf, Bilal ^{[1
,2
]}

Ibrahim, Ibrahim ^{[4
]}

Bat, Taha ^{[4
]}

Dickerson, Kathryn E. ^{[5
]}

机构：

[1] Univ Texas Southwestern, Dept Internal Med, Dallas, TX USA

[2] Univ Texas Southwestern, Dept Pediat, Dallas, TX USA

[3] Univ North Carolina Charlotte, Sch Data Sci, Charlotte, NC USA

[4] Univ Texas Southwestern Med Ctr, Dept Internal Med, Div Hematol & Oncol, Dallas, TX 75390 USA

[5] Univ Texas Southwestern Med Ctr, Dept Pediat, Div Hematol Oncol, 5323 Harry Hines Blvd, Dallas, TX 75390 USA

来源：

JOURNAL OF PEDIATRICS | 2022年 / 251卷

关键词：

THROMBOPOIESIS;

D O I：

10.1016/j.jpeds.2022.07.035

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

In this retrospective single-institution cohort study of 113 hospitalized pediatric patients with respiratory coronavirus disease 2019, those admitted to the intensive care unit or requiring mechanical ventilation had significantly higher immature platelet fractions than those who did not require intensive care unit-level care or ventilation. Immature platelet fraction may be an accessible biomarker for disease severity in pediatric respiratory coronavirus disease 2019. (J Pediatr 2022;251:187-9)

引用

页码：187 / 189

页数：3

共 13 条

[1]

[Anonymous], 2022, Children and COVID-19: State Data ReportA joint report from the American Academy of Pediatrics and the Children's Hospital Association summary of publicly reported data from 49 states, NYC, DC, PR, and GU

[2] Active thrombopoiesis is associated with worse severity and activity of chronic GVHD [J].

Bat, T. ;

Steinberg, S. M. ;

Childs, R. ;

Calvo, K. R. ;

Barrett, A. J. ;

Battiwalla, M. ;

Baird, K. ;

Zhang, D. ;

Pulanic, D. ;

Dunbar, C. E. ;

Pavletic, S. Z. .

BONE MARROW TRANSPLANTATION, 2013, 48 (12) :1569-1573

[3] Immature platelet fraction in predicting sepsis in critically ill patients [J].

De Blasi, Roberto Alberto ;

Cardelli, Patrizia ;

Costante, Alessandro ;

Sandri, Micol ;

Mercieri, Marco ;

Arcioni, Roberto .

INTENSIVE CARE MEDICINE, 2013, 39 (04) :636-643

[4] Severe Acute Respiratory Syndrome Coronavirus 2 Clinical Syndromes and Predictors of Disease Severity in Hospitalized Children and Youth [J].

Fernandes, Danielle M. ;

Oliveira, Carlos R. ;

Guerguis, Sandra ;

Eisenberg, Ruth ;

Choi, Jaeun ;

Kim, Mimi ;

Abdelhemid, Ashraf ;

Agha, Rabia ;

Agarwal, Saranga ;

Aschner, Judy L. ;

Avner, Jeffrey R. ;

Ballance, Cathleen ;

Bock, Joshua ;

Bhavsar, Sejal M. ;

Campbell, Melissa ;

Clouser, Katharine N. ;

Gesner, Matthew ;

Goldman, David L. ;

Hammerschlag, Margaret R. ;

Hymes, Saul ;

Howard, Ashley ;

Jung, Hee-jin ;

Kohlhoff, Stephan ;

Kojaoghlanian, Tsoline ;

Lewis, Rachel ;

Nachman, Sharon ;

Naganathan, Srividya ;

Paintsil, Elijah ;

Pall, Harpreet ;

Sy, Sharlene ;

Wadowski, Stephen ;

Zirinsky, Elissa ;

Cabana, Michael D. ;

Herold, Betsy C. .

JOURNAL OF PEDIATRICS, 2021, 230 :23-+

[5]

Horby PW, 2021, LANCET, V397, P1637, DOI 10.1016/S0140-6736(21)00676-0

[6] Association of Immature Platelets With Adverse Cardiovascular Outcomes [J].

Ibrahim, Homam ;

Schutt, Robert C. ;

Hannawi, Bashar ;

DeLao, Timothy ;

Barker, Colin M. ;

Kleiman, Neal S. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2014, 64 (20) :2122-2129

[7] Interleukin-6 stimulates thrombopoiesis through thrombopoietin: role in inflammatory thrombocytosis [J].

Kaser, A ;

Brandacher, G ;

Steurer, W ;

Kaser, S ;

Offner, FA ;

Zoller, H ;

Theurl, I ;

Widder, W ;

Molnar, C ;

Ludwiczek, O ;

Atkins, MB ;

Mier, JW ;

Tilg, H .

BLOOD, 2001, 98 (09) :2720-2725

[8] IL-6-based mortality risk model for hospitalized patients with COVID-19 [J].

Laguna-Goya, Rocio ;

Utrero-Rico, Alberto ;

Talayero, Paloma ;

Lasa-Lazaro, Maria ;

Ramirez-Fernandez, Angel ;

Naranjo, Laura ;

Segura-Tudela, Alejandro ;

Cabrera-Marante, Oscar ;

Rodriguez de Frias, Edgar ;

Garcia-Garcia, Rocio ;

Fernandez-Ruiz, Mario ;

Maria Aguado, Jose ;

Martinez-Lopez, Joaquin ;

Ana Lopez, Elena ;

Catalan, Mercedes ;

Serrano, Antonio ;

Paz-Artal, Estela .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2020, 146 (04) :799-+

[9] Immature platelets in COVID-19 infection [J].

Maitta, Robert W. .

BRITISH JOURNAL OF HAEMATOLOGY, 2021, 194 (03) :494-495

[10] Stability of measurement of the immature platelet fraction [J].

Ruisi, Mary M. ;

Psaila, Bethan ;

Ward, Mary J. ;

Villarica, Glynnis ;

Bussel, James B. .

AMERICAN JOURNAL OF HEMATOLOGY, 2010, 85 (08) :622-624

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