Aspects of B-Cell Non-Hodgkin's Lymphoma Development: A Transition from Immune-Reactivity to Malignancy

被引：17

作者：

Illes, A. ^{[2
]}

Varoczy, L. ^{[2
]}

Papp, G. ^{[1
]}

Wilson, P. C. ^{[3
,4
]}

Alex, P. ^{[5
]}

Jonsson, R. ^{[6
]}

Kovacs, T. ^{[1
]}

Konttinen, Y. T. ^{[7
,8
]}

Zeher, M. ^{[1
]}

Nakken, B. ^{[9
]}

Szodoray, P. ^{[1
]}

机构：

[1] Univ Debrecen, Div Clin Immunol, Dept Med 3, Med & Hlth Sci Ctr, H-4032 Debrecen, Hungary

[2] Univ Debrecen, Div Immune Hematol, Dept Med 3, Med & Hlth Sci Ctr, H-4032 Debrecen, Hungary

[3] Univ Chicago, Dept Rheumatol, Chicago, IL 60637 USA

[4] Gwenn Knapp Ctr Lupus Res, Chicago, IL USA

[5] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA

[6] Univ Bergen, Gade Inst, Broegelmann Res Lab, Bergen, Norway

[7] Univ Helsinki, Dept Med, ORTON Orthopaed Hosp Invalid Fdn, Helsinki, Finland

[8] COXA Hosp Joint Replacement, Tampere, Finland

[9] Univ Oslo, Inst Basic Med Sci, Dept Anat, Immunobiol Lab, Oslo, Norway

来源：

SCANDINAVIAN JOURNAL OF IMMUNOLOGY | 2009年 / 69卷 / 05期

关键词：

HEPATITIS-C VIRUS; NF-KAPPA-B; INTRACELLULAR SIGNALING MOLECULES; INDUCED CYTIDINE DEAMINASE; HUMAN MONOCLONAL-ANTIBODY; NECROSIS-FACTOR FAMILY; GASTRIC MALT LYMPHOMA; HELICOBACTER-PYLORI; SJOGRENS-SYNDROME; SALIVARY-GLANDS;

D O I：

10.1111/j.1365-3083.2009.02237.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The development of B-cell lymphomas is an intricate interplay among various pathogenic factors, leading to a multi-step process, encompassing various stages of B-cell maturation. Besides genetic abnormalities, a variety of environmental and microbial factors, as well as disproportional immune-regulatory processes lead to the malignant transformation. Yet, little is known about the exact chain of events, which lead from the physiological polyclonal B-cell activation as a response to exogenous antigens through oligoclonality to a monoclonal, uncontrolled, malignant B-cell proliferation. The aim of the present review was to summarize the potential harmful steps in the development of B-cell lymphomas, according to conventional and novel theories, and to depict therapeutic regimens presently in use as well as to envision future drug developments, beneficial in the battle against this lymphoid malignancy.

引用

页码：387 / 400

页数：14

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