In pursuit of pestalotiopsin A via zirconocene-mediated ring contraction

被引：16

作者：

Dong, Shuzhi ^{[1
]}

Parker, Gregory D. ^{[1
]}

Tei, Takahiro ^{[1
]}

Paquette, Leo A. ^{[1
]}

机构：

[1] Ohio State Univ, Evans Chem Labs, Columbus, OH 43210 USA

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 11期

关键词：

D O I：

10.1021/ol060827j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[graphics] An asymmetric route from the epimeric,- hydroxy esters 4 and 5 to the densely functionalized (+)-10 and (-)-10, respectively, is described. Either cyclobutanol can be made available as the predominant product. The levorotatory antipode has been transformed into the advanced intermediate 21 bearing side chains destined to become incorporated into the cyclononene ring of the title compound (1).

引用

页码：2429 / 2431

页数：3

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