Vaccines and Disease-Modifying Antirheumatic Drugs Practical Implications for the Rheumatologist

被引：47

作者：

Friedman, Marcia A. ^{[1
]}

Winthrop, Kevin L. ^{[2
]}

机构：

[1] Oregon Hlth & Sci Univ, Dept Rheumatol, Mail Code OP09,3181 Southwest Sam Jackson Pk Rd, Portland, OR 97239 USA

[2] Oregon Hlth & Sci Univ, Dept Infect Dis, 840 SW Gaines Rd, Portland, OR 97239 USA

来源：

RHEUMATIC DISEASE CLINICS OF NORTH AMERICA | 2017年 / 43卷 / 01期

关键词：

Vaccine; Rheumatoid arthritis; DMARD; Biologic; Anti-TNF; Rituximab; Immunogenicity; Efficacy; NECROSIS-FACTOR-ALPHA; B-VIRUS REACTIVATION; PNEUMOCOCCAL POLYSACCHARIDE VACCINATION; ADVISORY-COMMITTEE; ANTIBODY-RESPONSE; HERPES-ZOSTER; IMMUNIZATION PRACTICES; IMMUNE-RESPONSE; ARTHRITIS PATIENTS; INFLUENZA VACCINE;

D O I：

10.1016/j.rdc.2016.09.003

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Patients with rheumatoid arthritis are highly vulnerable to infections because of abnormalities in their immune system, and because of immunosuppressive effects of their medications. Vaccinations in this population are complicated by disease-modifying antirheumatic drugs, which also modulate or suppress the immune system and potentially decrease the immunogenicity and efficacy of the vaccines. We review the available data regarding the impact of rheumatoid arthritis therapy on the immunogenicity of various common vaccines. We also review rheumatoid arthritis specific vaccination recommendations, live vaccine safety concerns, and current gaps in our understanding of these issues."

引用

页码：1 / +

页数：14

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