Erythroid Kruppel like factor: from fishing expedition to gourmet meal

被引：57
作者：
Perkins, A [1 ]
机构：
[1] Monash Univ, Dept Physiol, Clayton, Vic 3168, Australia
来源：
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 1999年 / 31卷 / 10期
关键词：
D O I：
10.1016/S1357-2725(99)00083-7
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Erythroid Kruppel like factor (EKLF) is the founding member of a family of transcription factors which are defined by the presence of three C-terminal C2H2-type zinc fingers. Since its discovery 6 years ago, the study of EE;LF has been intense. In this review I will revisit the discovery of EKLF, and highlight recent advances in our understanding of how it interacts with other proteins to regulate erythroid gene transcription. The current knowledge of the biological role/s of EKLF in erythroid cell differentiation and globin gene switching are summarized. (C) 1999 Elsevier Science Ltd. All rights reserved.
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收藏
页码：1175 / 1192
页数：18
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