Somatic Mutations in theBRAF,KRAS,NRAS,EIF1AX, andTERTGenes: Diagnostic Value in Thyroid Neoplasms

被引：1
|
作者：
Kachko, V. A. [1 ]
Vanushko, V. E. [1 ]
Platonova, N. M. [1 ]
Abrosimov, A. Yu. [1 ]
Mel'nichenko, G. A. [1 ]
机构：
[1] Minist Hlth Russian Federat, Natl Med Res Ctr Endocrinol, Moscow, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2020年 / 169卷 / 05期
关键词：
thyroid neoplasms; BRAF; KRAS; NRAS; TERT; and EIF1AX mutations; TERT PROMOTER MUTATIONS; BRAF V600E MUTATION; CANCER; ASSOCIATION; PREVALENCE;
D O I：
10.1007/s10517-020-04951-1
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The feasibility of using molecular genetic markers associated with thyroid neoplasms and more aggressive course of the disease is now actively studied. We analyzed the diagnostic value of somatic mutations in the hot spots ofBRAF,KRAS,KRAS,EIF1AX, andTERTgenes in histological material from 153 patients with thyroid gland neoplasms.BRAFmutations (exon 15, codon area 600-601) were found in 54 patients,NRASmutations (exon 3, codon 61) were detected in 12 patients; mutationsKRAS,TERT, andEIF1AXgenes were not detected.
引用
收藏
页码：669 / 672
页数：4
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