Clinical Profile and Outcome of Children With Opsoclonus-Myoclonus Syndrome

被引：21

作者：

Singhi, Pratibha ^{[1
]}

Sahu, Jitendra Kumar ^{[1
]}

Sarkar, Jhuma ^{[1
]}

Bansal, Deepak ^{[2
]}

机构：

[1] Postgrad Inst Med Educ & Res, Div Pediat Neurol, Dept Pediat, Chandigarh 160012, India

[2] Postgrad Inst Med Educ & Res, Div Pediat Hematol Oncol, Dept Pediat, Chandigarh 160012, India

来源：

JOURNAL OF CHILD NEUROLOGY | 2014年 / 29卷 / 01期

关键词：

opsoclonus-myoclonus syndrome; neuroblastoma; paraneoplastic syndrome; NEUROBLASTOMA; RITUXIMAB;

D O I：

10.1177/0883073812471433

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The opsoclonus-myoclonus syndrome is a distinct disorder characterized by opsoclonus, myoclonus, and ataxia, along with marked irritability and behavioral changes. Worldwide, data on its epidemiology, clinical features, and outcome are scarce. The aim of the study was to determine the clinical profile and outcome of children with this disorder. A retrospective study of all children admitted with a diagnosis of opsoclonus-myoclonus from 2000 to 2012 was done. Outcome was assessed on follow-up by direct assessment and by telephonic interview. Eleven patients with a diagnosis of opsoclonus-myoclonus were admitted over a 12-year period. Of the 11, 4 had paraneoplastic etiology. Children with paraneoplastic opsoclonus had more relapses and a poor outcome as compared to an idiopathic group. Paraneoplastic opsoclonus had a poor outcome in our experience.

引用

页码：58 / 61

页数：4

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