Localization of B2 bradykinin receptor mRNA in the rat retina and sclerocornea

被引：18
|
作者：
Takeda, H
Kimura, Y
Higashida, H
Yokoyama, S
机构：
[1] Kanazawa Univ, Grad Sch Med, Dept Biophys Genet, Kanazawa, Ishikawa 9208640, Japan
[2] Kanazawa Univ, Sch Med, Dept Ophthalmol, Kanazawa, Ishikawa 9208640, Japan
来源：
IMMUNOPHARMACOLOGY | 1999年 / 45卷 / 1-3期
关键词：
bradykinin; B-2; receptor; in situ hybridization; retina; sclerocorneal junction;
D O I：
10.1016/S0162-3109(99)00057-0
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The expression of the B-2 bradykinin receptor (BKR) mRNA in the adult rat eye was investigated by RNA blot and in situ hybridization analyses. Blot hybridization analysis of poly(A)(+) RNA from the whole eye identified RNA species of 6000 and 4000 nucleotides, consistent with those observed in brain, lung, kidney and uterus. In situ hybridization analysis using digoxigenin-labeled riboprobes revealed intense labeling in the retinal ganglion cell layer and in a population of cells adjacent to the sclerocorneal junction. These data suggest that the B-2 BKR is involved in biological processes in both retina and sclerocornea. (C) 1999 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：51 / 55
页数：5
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