DNA Methylation Clocks and Their Predictive Capacity for Aging Phenotypes and Healthspan

被引：87

作者：

Bergsma, Tessa ^{[1
,2
]}

Rogaeva, Ekaterina ^{[1
,3
]}

机构：

[1] Univ Toronto, Tanz Ctr Res Neurodegenerat Dis, 60 Leonard Ave,4th Floor,4KD481, Toronto, ON M5T 0S8, Canada

[2] Univ Groningen, Fac Sci & Engn, Groningen, Netherlands

[3] Univ Toronto, Div Neurol, Dept Med, Toronto, ON, Canada

来源：

NEUROSCIENCE INSIGHTS | 2020年 / 15卷

基金：

美国国家卫生研究院;

关键词：

DNA methylation; chronological age; biological age; age-related disease; neurodegenerative disorders;

D O I：

10.1177/2633105520942221

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The number of age predictors based on DNA methylation (DNAm) profile is rising due to their potential in predicting healthspan and application in age-related illnesses, such as neurodegenerative diseases. The cumulative assessment of DNAm levels at age-related CpGs (DNAm clock) may reflect biological aging. Such DNAm clocks have been developed using various training models and could mirror different aspects of disease/aging mechanisms. Hence, evaluating several DNAm clocks together may be the most effective strategy in capturing the complexity of the aging process. However, various confounders may influence the outcome of these age predictors, including genetic and environmental factors, as well as technical differences in the selected DNAm arrays. These factors should be taken into consideration when interpreting DNAm clock predictions. In the current review, we discuss 15 reported DNAm clocks with consideration for their utility in investigating neurodegenerative diseases and suggest research directions towards developing a more optimal measure for biological aging.

引用

页数：11

共 96 条

[1]

BAKER GT, 1988, EXP GERONTOL, V23, P223, DOI 10.1016/0531-5565(88)90025-3

[2] DNA methylation aging clocks: challenges and recommendations [J].

Bell, Christopher G. ;

Lowe, Robert ;

Adams, Peter D. ;

Baccarelli, Andrea A. ;

Beck, Stephan ;

Bell, Jordana T. ;

Christensen, Brock C. ;

Gladyshev, Vadim N. ;

Heijmans, Bastiaan T. ;

Horvath, Steve ;

Ideker, Trey ;

Issa, Jean-Pierre J. ;

Kelsey, Karl T. ;

Marioni, Riccardo E. ;

Reik, Wolf ;

Relton, Caroline L. ;

Schalkwyk, Leonard C. ;

Teschendorff, Andrew E. ;

Wagner, Wolfgang ;

Zhang, Kang ;

Rakyan, Vardhman K. .

GENOME BIOLOGY, 2019, 20 (01)

[3] Eleven Telomere, Epigenetic Clock, and Biomarker-Composite Quantifications of Biological Aging: Do They Measure the Same Thing? [J].

Belsky, Daniel W. ;

Moffitt, Terrie E. ;

Cohen, Alan A. ;

Corcoran, David L. ;

Levine, Morgan E. ;

Prinz, Joseph A. ;

Schaefer, Jonathan ;

Sugden, Karen ;

Williams, Benjamin ;

Poulton, Richie ;

Caspi, Avshalom .

AMERICAN JOURNAL OF EPIDEMIOLOGY, 2018, 187 (06) :1220-1230

[4] Impact of early personal-history characteristics on the Pace of Aging: implications for clinical trials of therapies to slow aging and extend healthspan [J].

Belsky, Daniel W. ;

Caspi, Avshalom ;

Cohen, Harvey J. ;

Kraus, William E. ;

Ramrakha, Sandhya ;

Poulton, Richie ;

Moffitt, Terrie E. .

AGING CELL, 2017, 16 (04) :644-651

[5] Quantification of biological aging in young adults [J].

Belsky, Daniel W. ;

Caspi, Avshalom ;

Houts, Renate ;

Cohen, Harvey J. ;

Corcoran, David L. ;

Danese, Andrea ;

Harrington, HonaLee ;

Israel, Salomon ;

Levine, Morgan E. ;

Schaefer, Jonathan D. ;

Sugden, Karen ;

Williams, Ben ;

Yashin, Anatoli I. ;

Poulton, Richie ;

Moffitt, Terrie E. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 112 (30) :E4104-E4110

[6] Epigenetic Predictor of Age [J].

Bocklandt, Sven ;

Lin, Wen ;

Sehl, Mary E. ;

Sanchez, Francisco J. ;

Sinsheimer, Janet S. ;

Horvath, Steve ;

Vilain, Eric .

PLOS ONE, 2011, 6 (06)

[7] The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019 [J].

Buniello, Annalisa ;

MacArthur, Jacqueline A. L. ;

Cerezo, Maria ;

Harris, Laura W. ;

Hayhurst, James ;

Malangone, Cinzia ;

McMahon, Aoife ;

Morales, Joannella ;

Mountjoy, Edward ;

Sollis, Elliot ;

Suveges, Daniel ;

Vrousgou, Olga ;

Whetzel, Patricia L. ;

Amode, Ridwan ;

Guillen, Jose A. ;

Riat, Harpreet S. ;

Trevanion, Stephen J. ;

Hall, Peggy ;

Junkins, Heather ;

Flicek, Paul ;

Burdett, Tony ;

Hindorff, Lucia A. ;

Cunningham, Fiona ;

Parkinson, Helen .

NUCLEIC ACIDS RESEARCH, 2019, 47 (D1) :D1005-D1012

[8] VGF expression by T lymphocytes in patients with Alzheimer's disease [J].

Busse, Stefan ;

Steiner, Johann ;

Glorius, Sarah ;

Dobrowolny, Henrik ;

Greiner-Bohl, Sabrina ;

Mawrin, Christian ;

Bommhardt, Ursula ;

Hartig, Roland ;

Bogerts, Bernhard ;

Busse, Mandy .

ONCOTARGET, 2015, 6 (17) :14843-14851

[9] Epigenetic Aging and Immune Senescence in Women With Insomnia Symptoms: Findings From the Women's Health Initiative Study [J].

Carroll, Judith E. ;

Irwin, Michael R. ;

Levine, Morgan ;

Seeman, Teresa E. ;

Absher, Devin ;

Assimes, Themistocles ;

Horvath, Steve .

BIOLOGICAL PSYCHIATRY, 2017, 81 (02) :136-144

[10] Differential preservation of AMPA receptor subunits in the hippocampi of Alzheimer's disease patients according to Braak stage [J].

Carter, TL ;

Rissman, RA ;

Mishizen-Eberz, AJ ;

Wolfe, BB ;

Hamilton, RL ;

Gandy, S ;

Armstrong, DM .

EXPERIMENTAL NEUROLOGY, 2004, 187 (02) :299-309

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