The role of the dorsolateral prefrontal cortex in early threat processing: a TMS study

被引：34
作者：
Sagliano, Laura [1 ]
D'Olimpio, Francesca [1 ]
Panico, Francesco [1 ]
Gagliardi, Serena [1 ]
Trojano, Luigi [1 ]
机构：
[1] Univ Naples 2, Dept Psychol, Viale Ellitt 31, I-81100 Caserta, Italy
来源：
SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE | 2016年 / 11卷 / 12期
关键词：
attention; anxiety; DLPFC; TMS; threat; TRANSCRANIAL MAGNETIC STIMULATION; ATTENTIONAL BIAS; EMOTIONAL INFORMATION; TRAIT ANXIETY; RTMS;
D O I：
10.1093/scan/nsw105
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Previous studies demonstrated that excitatory (high frequency) offline transcranial magnetic stimulation (TMS) over the left and right dorsolateral prefrontal cortex (DLPFC) modulates attention allocation on threatening stimuli in non-clinical samples. These studies only employed offline TMS protocol that did not allow investigating the effect of the stimulation on the early stage of threat processing. In this study, the role of the right and left dorsolateral prefrontal cortex in early threat processing was investigated in high and low anxious individuals by means of an inhibitory single-pulse online TMS protocol. Our results demonstrated the role of the left DLPFC in an early stage of threat processing and that this effect is modulated by individuals' anxiety level. The inhibitory stimulation of the left DLPFC determined a disengagement bias in high anxious individuals, while the same stimulation determined an attentional avoidance in low anxious individuals. The findings of the present study suggest that right and left DLPFC are differently involved in early threat processing of healthy individuals.
引用
收藏
页码：1992 / 1998
页数：7
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