A dichotomy in the lipophilicity of natural estrogens, xenoestrogens, and phytoestrogens

被引：28
作者：
Cunningham, AR
Klopman, G
Rosenkranz, HS
机构：
[1] UNIV PITTSBURGH,DEPT ENVIRONM & OCCUPAT HLTH,PITTSBURGH,PA 15261
[2] CASE WESTERN RESERVE UNIV,DEPT CHEM,CLEVELAND,OH 44106
来源：
ENVIRONMENTAL HEALTH PERSPECTIVES | 1997年 / 105卷
关键词：
CASE/MULTICASE; cancer; estrogens; lipophilicity;
D O I：
10.2307/3433386
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
Using two independent analyses, it is demonstrated that natural (e.g., estradiol) ard some xenoestrogens (e.g., methoxychlor metabolite) are characterized by a lipophilic region that is absent in nonestrogens as well as in phytoestrogens. It is suggested that this lipophilic region affects binding to specific receptors and may, in fact, differentiate harmful from beneficial estrogens.
引用
收藏
页码：665 / 668
页数：4
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