Molecular mechanisms for targeted ASD treatments

被引:26
作者
Basilico, Bernadette [1 ]
Morandell, Jasmin [1 ]
Novarino, Gaia [1 ]
机构
[1] IST Austria, Klosterneuburg, Austria
基金
奥地利科学基金会;
关键词
FRAGILE-X-SYNDROME; MOUSE MODEL; SYNAPTIC PLASTICITY; NEURONAL MIGRATION; TRANSCRIPTIONAL REGULATION; PROTEIN-SYNTHESIS; ANGELMAN SYNDROME; SOCIAL DEFICITS; CRITICAL-PERIOD; RISK GENES;
D O I
10.1016/j.gde.2020.06.004
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The possibility to generate construct valid animal models enabled the development and testing of therapeutic strategies targeting the core features of autism spectrum disorders (ASDs). At the same time, these studies highlighted the necessity of identifying sensitive developmental time windows for successful therapeutic interventions. Animal and human studies also uncovered the possibility to stratify the variety of ASDs in molecularly distinct subgroups, potentially facilitating effective treatment design. Here, we focus on the molecular pathways emerging as commonly affected by mutations in diverse ASD-risk genes, on their role during critical windows of brain development and the potential treatments targeting these biological processes.
引用
收藏
页码:126 / 137
页数:12
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