Patient preference study for different characteristics of systemic psoriasis treatments (Protimisis)

被引:7
作者
Rigopoulos, D. [1 ]
Ioannides, D. [2 ]
Chaidemenos, G.
Kallidis, P.
Voultsidou, A. [3 ]
Matekovits, A.
Soura, E. [1 ]
机构
[1] Univ Athens, Andreas Sygros Hosp, Med Sch, Dept Dermatol Venereol 1, 5 Dragoumi Str, Athens 16121, Greece
[2] Aristotle Univ Thessaloniki, Dept Dermatol 1, Thessaloniki, Greece
[3] Gen Hosp Katerine, Katerine, Greece
关键词
biologics; patient preference; psoriasis; systemic treatments; DISCRETE-CHOICE EXPERIMENTS; RANDOMIZED CONTROLLED-TRIAL; TO-SEVERE PSORIASIS; QUALITY-OF-LIFE; PLAQUE PSORIASIS; INFLIXIMAB INDUCTION; DOUBLE-BLIND; PHASE-III; REGISTRY; THERAPY;
D O I
10.1111/dth.12592
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
The Protimisis study was a multicenter, cross-sectional study investigating the relative importance and economic value that patients assign to different characteristics of systemic psoriasis treatments. Treatment preferences were investigated with the DCE methodology and patients had to decide over the most important aspects of different psoriasis treatments. A questionnaire regarding demographic data/medical history and the DLQI and EQ-5D-3L questionnaires were also completed. A total of 310 patients were included. Out of those, 37.4% reported using oral medications for psoriasis as their most recent treatment, while the remaining patients reported treatment with injections once per week (14.8%), injections twice per week (7.4%), injections once every three months (29.4%) and intravenous injections every two months (8.4%) as their most recent treatment. Mean DLQI score was 6.6 (SD 6.5), and in the EQ-5D-3L index, 71.0% of patients reported having problems with anxiety or depression. DCE analysis showed a clear preference for treatments with longer dosing intervals, rapid onset of action, lasting clinical response, low risk of SAEs and lower cost. The risk of SAEs was the most important treatment characteristic (54% of patients). Older patients showed less concern for safety matters than younger patients. The highest willingness-to-pay was recorded for treatments with longer dosing intervals and for safer treatment options.
引用
收藏
页数:8
相关论文
共 50 条
  • [31] Systemic Monotherapy Treatments for Generalized Pustular Psoriasis: A Systematic Review
    Zhou, Linghong Linda
    Georgakopoulos, Jorge R.
    Ighani, Arvin
    Yeung, Jensen
    JOURNAL OF CUTANEOUS MEDICINE AND SURGERY, 2018, 22 (06) : 591 - 601
  • [32] The impact of systemic psoriasis treatments on human papillomavirus activation and propagation
    Korecka, Katarzyna
    Wisniewska-Szymanska, Anna
    Mikiel, Dominik
    AUSTRALASIAN JOURNAL OF DERMATOLOGY, 2022, 63 (03) : 293 - 302
  • [33] Systemic treatments in childhood psoriasis: a French multicentre study on 154 children
    Charbit, L.
    Mahe, E.
    Phan, A.
    Chiaverini, C.
    Boralevi, F.
    Bourrat, E.
    Lasek, A.
    Maruani, A.
    Aubin, F.
    Droitcourt, C.
    Barbarot, S.
    Mallet, S.
    Mazereeuw-Hautier, J.
    Begon, E.
    Abasq, C.
    Plantin, P.
    Souillet, A. L.
    Hadj-Rabia, S.
    Bursztejn, A. -C.
    BRITISH JOURNAL OF DERMATOLOGY, 2016, 174 (05) : 1118 - 1121
  • [34] Patient satisfaction with treatments for moderate-to-severe plaque psoriasis in clinical practice
    Duffin, K. Callis
    Yeung, H.
    Takeshita, J.
    Krueger, G. G.
    Robertson, A. D.
    Troxel, A. B.
    Shin, D. B.
    Van Voorhees, A. S.
    Gelfand, J. M.
    BRITISH JOURNAL OF DERMATOLOGY, 2014, 170 (03) : 672 - 680
  • [35] Patients’ Vehicle Preference for Corticosteroid Treatments of Scalp Psoriasis
    Steven R. Feldman
    Tamara S. Housman
    American Journal of Clinical Dermatology, 2003, 4 : 221 - 224
  • [36] Patients' and Physicians' Preferences for Systemic Psoriasis Treatments: A Nationwide Comparative Discrete Choice Experiment (PsoCompare)
    Schaarschmidt, Marthe-Lisa
    Herr, Raphael
    Gutknecht, Mandy
    Wroblewska, Katharina
    Gerdes, Sascha
    Sticherling, Michael
    Augustin, Matthias
    Peitsch, Wiebke K.
    ACTA DERMATO-VENEREOLOGICA, 2018, 98 (02) : 200 - 205
  • [37] Cutaneous and systemic improvements in psoriasis patients after different biologic treatments in a real-world longitudinal prospective study
    Epipode Ntawuyamara
    Baoqing Deng
    Yanhua Liang
    Scientific Reports, 15 (1)
  • [38] Italian guidelines on the systemic treatments of moderate-to-severe plaque psoriasis
    Gisondi, P.
    Altomare, G.
    Ayala, F.
    Bardazzi, F.
    Bianchi, L.
    Chiricozzi, A.
    Costanzo, A.
    Conti, A.
    Dapavo, P.
    De Simone, C.
    Foti, C.
    Naldi, L.
    Offidani, A.
    Parodi, A.
    Piaserico, S.
    Prignano, F.
    Rongioletti, F.
    Stingeni, L.
    Talamonti, M.
    Girolomoni, G.
    JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2017, 31 (05) : 774 - 790
  • [39] Cardiovascular safety of systemic psoriasis treatments: A prospective cohort study in the BIOBADADERM registry
    Lluch-Galcera, Juan Jose
    Carrascosa, Jose Manuel
    Gonzalez-Quesada, Alicia
    Sahuquillo-Torralba, Antonio
    Rivera-Diaz, Raquel
    Dauden, Esteban
    Belinchon, Isabel
    Gomez-Garcia, Francisco Jose
    Herrera-Acosta, Enrique
    Ruiz-Genao, Diana P.
    Lopez-Estebaranz, Jose Luis
    Baniandres-Rodriguez, Ofelia
    Ferran, Marta
    de la Cueva, Pablo
    Rodriguez, Lourdes
    Mateu, Almudena
    Riera-Monroig, Josep
    Ruiz-Carrascosa, Jose Carlos
    Ara-Martin, Mariano
    Abalde-Pintos, Maria Teresa
    Roncero-Riesco, Monica
    Pujol-Marco, Conrad
    Garcia-Donoso, Carmen
    Llamas-Velasco, Mar
    Del Alcazar, Elena
    Suarez-Perez, Jorge Alonso
    Rodriguez-Sanchez, Belen
    Diez-Madueno, Kevin
    Ruiz-Villaverde, Ricardo
    Lezcano-Biosca, Victoria
    Gonzalez-Sixto, Beatriz
    Descalzo, Miguel Angel
    Garcia-Doval, Ignacio
    JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2025,
  • [40] Patient Preferences for Topical Psoriasis Treatments are Diverse and Difficult to Predict
    Lars Iversen
    Henny B. Jakobsen
    Dermatology and Therapy, 2016, 6 : 273 - 285