Aerosol Delivery of siRNA to the Lungs. Part 2: Nanocarrier-based Delivery Systems

被引：20
作者：
Youngren-Ortiz, Susanne R. [1 ]
Gandhi, Nishant S. [1 ]
Espana-Serrano, Laura [1 ]
Chougule, Mahavir B. [1 ,2 ]
机构：
[1] Univ Hawaii, Daniel K Inouye Coll Pharm, Dept Pharmaceut Sci, Translat Drug Delivery Res Lab, 200 West Kawili St, Hilo, HI 96720 USA
[2] Univ Hawaii Manoa, Canc Res Ctr, Nat Prod & Expt Therapeut Program, Honolulu, HI 96813 USA
来源：
KONA POWDER AND PARTICLE JOURNAL | 2017年 / 34期
基金：
美国国家卫生研究院;
关键词：
siRNA; nanocarrier; nanoparticle; aerosolization; pulmonary; lung; SOLID LIPID NANOPARTICLES; SMALL INTERFERING RNA; CONTROLLED/LIVING RADICAL POLYMERIZATION; MESOPOROUS SILICA NANOPARTICLES; CELL-PENETRATING PEPTIDES; DRY POWDER INHALER; IN-VIVO; PLGA NANOPARTICLES; CURRENT PROGRESS; DRUG-DELIVERY;
D O I：
10.14356/kona.2017005
中图分类号：
TQ [化学工业];
学科分类号：
0817 ;
摘要：
In this article, applications of engineered nanoparticles containing siRNA for inhalation delivery are reviewed and discussed. Diseases with identiied protein malfunctions may be mitigated through the use of well-designed siRNA therapeutics. The inhalation route of administration provides local delivery of siRNA therapeutics to the lungs for various pulmonary diseases. A siRNA delivery system can be used to overcome the barriers of pulmonary delivery, such as anatomical barriers, mucociliary clearance, cough clearance, and alveolar macrophage clearance. Apart from naked siRNA aerosol delivery, previously studied siRNA carrier systems include those of lipidic, polymeric, peptide, or inorganic origin. These delivery systems can achieve pulmonary delivery through the generation of an aerosol via an inhaler or nebulizer. The preparation methodologies for these siRNA nanocarrier systems will be discussed herein. The use of inhalable nanocarrier siRNA delivery systems have barriers to their effective delivery, but overcoming these constraints while formulating a safe and effective delivery system will offer unique advances to the field of inhaled medicine.
引用
收藏
页码：44 / 69
页数：26
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