FGF6 in myogenesis

被引：51

作者：

Armand, Anne-Sophie

Laziz, Iman

Chanoine, Christophe

机构：

[1] Royal Netherlands Acad Sci, Hubrecht Lab, Utrecht, Netherlands

[2] Royal Netherlands Acad Sci, Interuniv Cardiol Inst Netherlands, Utrecht, Netherlands

[3] Univ Paris 05, Ctr Saints Peres, CNRS, UMR 7060,Equipe Biol Dev & Differenciat Neuromusc, F-75270 Paris 06, France

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2006年 / 1763卷 / 08期

关键词：

FGF6; myogenesis; growth factor; muscle regeneration; development;

D O I：

10.1016/j.bbamcr.2006.06.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Important functions in myogenesis have been proposed for FGF6, a member of the fibroblast growth factor family accumulating almost exclusively in the myogenic lineage. However, the analyses of Fgf6 (-/-) mutant mice gave contradictory results and the role of FGF6 during myogenesis remained largely unclear. Recent reports support the concept that FGF6 has a dual function in muscle regeneration, stimulating myoblast proliferation/migration and muscle differentiation/hypertrophy in a dose-dependent manner. The alternative use of distinct signaling pathways recruiting either FGFR1 or FGFR4 might explain the dual role of FGF6 in myogenesis. A role for FGF6 in the maintenance of a reserve pool of progenitor cells in the skeletal muscle has been also strongly suggested. The aim of this review is to summarize our knowledge on the involvement of FGF6 in myogenesis. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：773 / 778

页数：6

共 62 条

[11] Fibroblast growth factor receptor-1 (FGFR-1) is essential for normal neural tube and limb development
Deng, CX
Bedford, M
Li, CL
Xu, XL
Yang, X
Dunmore, J
Leder, P
[J]. DEVELOPMENTAL BIOLOGY, 1997, 185 (01) : 42 - 54
[12] MURINE FGFR-1 IS REQUIRED FOR EARLY POSTIMPLANTATION GROWTH AND AXIAL ORGANIZATION
DENG, CX
WYNSHAWBORIS, A
SHEN, MM
DAUGHERTY, C
ORNITZ, DM
LEDER, P
[J]. GENES & DEVELOPMENT, 1994, 8 (24) : 3045 - 3057
[13] Doetschman T, 1999, LAB ANIM SCI, V49, P137
[14] Delivery of FGF genes to wound repair cells enhances arteriogenesis and myogenesis in skeletal muscle
Doukas, J
Blease, K
Craig, D
Ma, CL
Chandler, LA
Sosnowski, BA
Pierce, GF
[J]. MOLECULAR THERAPY, 2002, 5 (05) : 517 - 527
[15] Fiore F, 1997, INT J DEV BIOL, V41, P639
[16] Skeletal muscle regeneration is not impaired in Fgf6 -/- mutant mice
Fiore, F
Sébille, A
Birnbaum, D
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2000, 272 (01) : 138 - 143
[17] Growth hormone and the insulin-like growth factor system in myogenesis
Florini, JR
Ewton, DZ
Coolican, SA
[J]. ENDOCRINE REVIEWS, 1996, 17 (05) : 481 - 517
[18] A role for FGF-6 in skeletal muscle regeneration
Floss, T
Arnold, HH
Braun, T
[J]. GENES & DEVELOPMENT, 1997, 11 (16) : 2040 - 2051
[19] Calcineurin activity is required for the initiation of skeletal muscle differentiation
Friday, BB
Horsley, V
Pavlath, GK
[J]. JOURNAL OF CELL BIOLOGY, 2000, 149 (03) : 657 - 665
[20] COLOCALIZATION OF BFGF AND THE MYOGENIC REGULATORY GENE MYOGENIN IN DYSTROPHIC MDX-MUSCLE PRECURSORS AND YOUNG MYOTUBES IN-VIVO
GARRETT, KL
ANDERSON, JE
[J]. DEVELOPMENTAL BIOLOGY, 1995, 169 (02) : 596 - 608

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