Efficacy of ambruticin analogs in a murine model of coccidioidomycosis

被引：19

作者：

Shubitz, Lisa F.

Galgiani, John N.

Tian, Zong-Qiang

Zhong, Ziyang

Timmermans, Pieter

Katz, Leonard

机构：

[1] Univ Arizona, Valley Fever Ctr Excellence, Dept Vet Sci & Microbiol, Tucson, AZ 85723 USA

[2] Univ Arizona, Valley Fever Ctr Excellence, Dept Med, Tucson, AZ 85723 USA

[3] So Arizona Vet Hlth Care Adm, Tucson, AZ USA

[4] Kosan Biosci Inc, Hayward, CA USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2006年 / 50卷 / 10期

关键词：

D O I：

10.1128/AAC.00670-06

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Ambruticin S, an antifungal cyclopropyl-pyran acid, showed curative effects against murine coccidioidal infection. Two analogs of this compound with greater in vitro potency were tested against lethal murine Coccidioides infection. Both improved the survival of mice over that of controls; one resulted in near-sterilization of infection.

引用

页码：3467 / 3469

页数：3

共 8 条

[1] Update on antifungals targeted to the cell wall:: focus on β-1,3-glucan synthase inhibitors
Georgopapadakou, NH
[J]. EXPERT OPINION ON INVESTIGATIONAL DRUGS, 2001, 10 (02) : 269 - 280
[2] On the mechanism of action of the myxobacterial fungicide ambruticin
Knauth, P
Reichenbach, H
[J]. JOURNAL OF ANTIBIOTICS, 2000, 53 (10) : 1182 - 1190
[3] THERAPEUTIC PROPERTIES OF ORAL AMBRUTICIN (W7783) IN EXPERIMENTAL PULMONARY COCCIDIOIDOMYCOSIS OF MICE
LEVINE, HB
RINGEL, SM
COBB, JM
[J]. CHEST, 1978, 73 (02) : 202 - 206
[4] National Committee for Clinical Laboratory Standards, 2002, M38A NAT COMM CLIN L
[5] INVITRO AND INVIVO STUDIES OF AMBRUTICIN (W7783) - NEW CLASS OF ANTIFUNGAL ANTIBIOTICS
RINGEL, SM
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1978, 13 (05) : 762 - 769
[6] INVIVO STUDIES WITH AMBRUTICIN IN MURINE HISTOPLASMOSIS
SHADOMY, S
UTZ, CJ
WHITE, S
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1978, 14 (01) : 95 - 98
[7] Protection of mice against Coccidioides immitis intranasal infection by vaccination with recombinant antigen 2/PRA
Shubitz, L
Peng, T
Perrill, R
Simons, J
Orsborn, K
Galgiani, JN
[J]. INFECTION AND IMMUNITY, 2002, 70 (06) : 3287 - 3289
[8] WILLIAMS DM, 1979, AM REV RESPIR DIS, V120, P837

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