Organocatalyzed Formal [4+2] Cycloaddition of in situ Generated Azoalkenes with Arylacetic Acids: An Efficient Approach to the Synthesis of 4,5-Dihydropyridazin-3(2H)-ones

被引：35

作者：

Li, Xuanyi ^{[1
,2
]}

Gai, Kuo ^{[1
,2
]}

Yuan, Zhenbo ^{[1
,2
]}

Wu, Jie ^{[1
,2
]}

Lin, Aijun ^{[1
,2
]}

Yao, Hequan ^{[1
,2
]}

机构：

[1] China Pharmaceut Univ, SKLNM, Nanjing 210009, Peoples R China

[2] China Pharmaceut Univ, Sch Pharm, Dept Med Chem, Nanjing 210009, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2015年 / 357卷 / 16-17期

基金：

中国国家自然科学基金;

关键词：

1,2-diaza-1,3-dienes; 4,5-dihydropyridazin-3(2H)-ones; isothiourea catalysis; DYNAMIC KINETIC RESOLUTION; ASYMMETRIC-SYNTHESIS; ACYL; 1,2-DIAZA-1,3-DIENES; BENZOTETRAMISOLE; LACTONIZATION; ANNULATION; ANHYDRIDES; REACTIVITY; INDOLES;

D O I：

10.1002/adsc.201500645

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

An unprecedented [4+2] cycloaddition of in situ generated azoalkenes with arylacetic acids has been developed under the catalysis of isothiourea. The reaction provided an efficient approach to the synthesis of 4,5-dihydropyridazin-3(2H)-one derivatives in moderate to good yields (up to 95%).

引用

页码：3479 / 3484

页数：6

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