Organocatalyzed Formal [4+2] Cycloaddition of in situ Generated Azoalkenes with Arylacetic Acids: An Efficient Approach to the Synthesis of 4,5-Dihydropyridazin-3(2H)-ones

被引：35
|
作者：
Li, Xuanyi [1 ,2 ]
Gai, Kuo [1 ,2 ]
Yuan, Zhenbo [1 ,2 ]
Wu, Jie [1 ,2 ]
Lin, Aijun [1 ,2 ]
Yao, Hequan [1 ,2 ]
机构：
[1] China Pharmaceut Univ, SKLNM, Nanjing 210009, Peoples R China
[2] China Pharmaceut Univ, Sch Pharm, Dept Med Chem, Nanjing 210009, Peoples R China
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2015年 / 357卷 / 16-17期
基金：
中国国家自然科学基金;
关键词：
1,2-diaza-1,3-dienes; 4,5-dihydropyridazin-3(2H)-ones; isothiourea catalysis; DYNAMIC KINETIC RESOLUTION; ASYMMETRIC-SYNTHESIS; ACYL; 1,2-DIAZA-1,3-DIENES; BENZOTETRAMISOLE; LACTONIZATION; ANNULATION; ANHYDRIDES; REACTIVITY; INDOLES;
D O I：
10.1002/adsc.201500645
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
An unprecedented [4+2] cycloaddition of in situ generated azoalkenes with arylacetic acids has been developed under the catalysis of isothiourea. The reaction provided an efficient approach to the synthesis of 4,5-dihydropyridazin-3(2H)-one derivatives in moderate to good yields (up to 95%).
引用
收藏
页码：3479 / 3484
页数：6
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