Synthesis of 2-Substituted (2R,4R)-3-(3-Mercapto-Propionyl)Thiazolidine-4-Carboxylic Acids

被引：12

作者：

Ershov, A. Yu. ^{[1
]}

Nasledov, D. G. ^{[1
]}

Lagoda, I. V. ^{[2
]}

Shamanin, V. V. ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Macromol Cpds, St Petersburg 199004, Russia

[2] Minist Def Russian Federat, State Sci Res & Testing Inst Mil Med, Sci Res & Testing Ctr Biomed Def, St Petersburg 195043, Russia

来源：

CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2014年 / 50卷 / 07期

关键词：

aldehydes; 2-substituted 3-(3-mercaptopropionyl)thiazolidine-4-carboxylic acids; L-cysteine; angiotensin converting enzyme inhibitors; CONVERTING ENZYME-INHIBITORS; THIOL COMPOUNDS; DERIVATIVES; DESIGN;

D O I：

10.1007/s10593-014-1560-x

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The natural amino acid L-cysteine, commercially available aldehydes, and 3-(acetylsulfanyl)propionyl chloride were used for the synthesis of 2-substituted (2R,4R)-3-(3-mercaptopropionyl)thiazolidine-4-carboxylic acids, potential antihypertensive drugs with angiotensin converting enzyme inhibiting action.

引用

页码：1032 / 1038

页数：7

共 22 条

[1] Complexation of enalapril maleate with β-cyclodextrin:: NMR spectroscopic study in solution [J].

Ali, Syed Mashhood ;

Maheshwari, Arti ;

Asmat, Fahmeena ;

Koketsu, Mamoru .

QUIMICA NOVA, 2006, 29 (04) :685-688

[2] Angiotensin-converting enzyme inhibitors [J].

Brown, NJ ;

Vaughan, DE .

CIRCULATION, 1998, 97 (14) :1411-1420

[3]

Butvin P, 1998, CHEM PAP-CHEM ZVESTI, V52, P205

[4]

Chipens G. I., 1984, CHEM HETEROCYCL COMP, V1443, P1189

[5] ANTIMETABOLITEN .1. SYNTHESE UND EIGENSCHAFTEN VON SULFONSAURE-ANALOGA DER SIGMA-AMINOLAVULINSAURE [J].

DAENIKER, HU ;

DRUEY, J .

HELVETICA CHIMICA ACTA, 1957, 40 (07) :2148-2156

[6] Design, synthesis and biological evaluation of 2-(substituted phenyl)thiazolidine-4-carboxylic acid derivatives as novel tyrosinase inhibitors [J].

Ha, Young Mi ;

Park, Yun Jung ;

Lee, Ji Yeon ;

Park, Daeui ;

Choi, Yeon Ja ;

Lee, Eun Kyeong ;

Kim, Ji Min ;

Kim, Jin-Ah ;

Park, Ji Young ;

Lee, Hye Jin ;

Moon, Hyung Ryong ;

Chung, Hae Young .

BIOCHIMIE, 2012, 94 (02) :533-540

[7]

Iwao J., US Pat. Appl., Patent No. 4423054

[8]

KATO E, 1985, CHEM PHARM BULL, V33, P74

[9]

McOmie J. F. W., 1976, PROTECTIVE GROUPS OR, P191

[10]

Negrete G. R., 2011, US Pat. Appl., Patent No. 2011268653

← 1 2 3 →