Synthesis of 2-Substituted (2R,4R)-3-(3-Mercapto-Propionyl)Thiazolidine-4-Carboxylic Acids

被引:12
作者
Ershov, A. Yu. [1 ]
Nasledov, D. G. [1 ]
Lagoda, I. V. [2 ]
Shamanin, V. V. [1 ]
机构
[1] Russian Acad Sci, Inst Macromol Cpds, St Petersburg 199004, Russia
[2] Minist Def Russian Federat, State Sci Res & Testing Inst Mil Med, Sci Res & Testing Ctr Biomed Def, St Petersburg 195043, Russia
关键词
aldehydes; 2-substituted 3-(3-mercaptopropionyl)thiazolidine-4-carboxylic acids; L-cysteine; angiotensin converting enzyme inhibitors; CONVERTING ENZYME-INHIBITORS; THIOL COMPOUNDS; DERIVATIVES; DESIGN;
D O I
10.1007/s10593-014-1560-x
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The natural amino acid L-cysteine, commercially available aldehydes, and 3-(acetylsulfanyl)propionyl chloride were used for the synthesis of 2-substituted (2R,4R)-3-(3-mercaptopropionyl)thiazolidine-4-carboxylic acids, potential antihypertensive drugs with angiotensin converting enzyme inhibiting action.
引用
收藏
页码:1032 / 1038
页数:7
相关论文
共 22 条
[1]   Complexation of enalapril maleate with β-cyclodextrin:: NMR spectroscopic study in solution [J].
Ali, Syed Mashhood ;
Maheshwari, Arti ;
Asmat, Fahmeena ;
Koketsu, Mamoru .
QUIMICA NOVA, 2006, 29 (04) :685-688
[2]   Angiotensin-converting enzyme inhibitors [J].
Brown, NJ ;
Vaughan, DE .
CIRCULATION, 1998, 97 (14) :1411-1420
[3]  
Butvin P, 1998, CHEM PAP-CHEM ZVESTI, V52, P205
[4]  
Chipens G. I., 1984, CHEM HETEROCYCL COMP, V1443, P1189
[5]   ANTIMETABOLITEN .1. SYNTHESE UND EIGENSCHAFTEN VON SULFONSAURE-ANALOGA DER SIGMA-AMINOLAVULINSAURE [J].
DAENIKER, HU ;
DRUEY, J .
HELVETICA CHIMICA ACTA, 1957, 40 (07) :2148-2156
[6]   Design, synthesis and biological evaluation of 2-(substituted phenyl)thiazolidine-4-carboxylic acid derivatives as novel tyrosinase inhibitors [J].
Ha, Young Mi ;
Park, Yun Jung ;
Lee, Ji Yeon ;
Park, Daeui ;
Choi, Yeon Ja ;
Lee, Eun Kyeong ;
Kim, Ji Min ;
Kim, Jin-Ah ;
Park, Ji Young ;
Lee, Hye Jin ;
Moon, Hyung Ryong ;
Chung, Hae Young .
BIOCHIMIE, 2012, 94 (02) :533-540
[7]  
Iwao J., US Pat. Appl., Patent No. 4423054
[8]  
KATO E, 1985, CHEM PHARM BULL, V33, P74
[9]  
McOmie J. F. W., 1976, PROTECTIVE GROUPS OR, P191
[10]  
Negrete G. R., 2011, US Pat. Appl., Patent No. 2011268653