The modification of PLA and PLGA using electron-beam radiation

被引:32
作者
Leonard, Dermot J. [1 ]
Pick, Louise T. [1 ]
Farrar, David F. [2 ]
Dickson, Glenn R. [3 ]
Orr, John F. [1 ]
Buchanan, Fraser J. [1 ]
机构
[1] Queens Univ Belfast, Sch Mech & Aerosp Engn, Belfast BT9 5AH, Antrim, North Ireland
[2] Smith & Nephew Grp Res Ctr, York YO10 5DF, N Yorkshire, England
[3] Musgrave Pk Hosp, Dept Trauma & Orthopaed Surg, Belfast BT9 7JB, Antrim, North Ireland
关键词
bioabsorption; electron beam; polylactic acid; polyglycolic acid; surface modification; MONTE-CARLO CODE; C-LANGUAGE; BIODEGRADABLE POLYMERS; DEGRADATION; CASINO; SURGERY; ACID); PLLA;
D O I
10.1002/jbm.a.31998
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
The degradable polymers polylactide (PLA) and polylactide-co-glycolide (PLGA) have found widespread use in modern medical practice. However, their slow degradation rates and tendency to lose strength before mass have caused problems. The aim of this study was to ascertain whether treatment with e-beam radiation could address these problems. Samples of PLA and PLGA were manufactured and placed in layered stacks, 8.1 mm deep, before exposure to 50 kGy of e-beam radiation from a 1.5 MeV accelerator. Gel permeation chromatography testing showed that the molecular weight of both materials was depth-dependent following irradiation, with samples nearest to the treated surface showing a reduced molecular weight. Samples deeper than 5.4 mm were unaffected. Computer modeling of the transmission of a 1.5 MeV e-beam in these materials corresponded well with these findings. An accelerated mass-loss study of the treated materials found that the samples nearest the irradiated surface initiated mass loss earlier, and at later stages showed an increased percentage mass loss. It was concluded that e-beam radiation could modify the degradation of bioabsorbable polymers to potentially improve their performance in medical devices, specifically for improved orthopedic fixation. (C) 2008 Wiley Periodicals, Inc. J Biomed Mater Res 89A: 567-574, 2009
引用
收藏
页码:567 / 574
页数:8
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