Brain-Derived Neurotrophic Factor (BDNF): Role of this neurotrophin in cardiovascular physiopathology

被引：7
|
作者：
Lorgis, L. [1 ,2 ]
Amoureux, S. [1 ]
Vergely, C. [1 ]
Zeller, M. [1 ,2 ]
Cottin, Y. [1 ,2 ]
Rochette, L. [1 ]
机构：
[1] Fac Med & Pharm Dijon, LPPCE, IFR Sante STIC, F-21033 Dijon, France
[2] CHU Dijon, Serv Cardiol, Dijon, France
来源：
ANNALES DE CARDIOLOGIE ET D ANGEIOLOGIE | 2009年 / 58卷 / 02期
关键词：
Neurotrophins; BDNF; Cardiovascular; Myocardial infarction; REDUCED PLASMA-LEVELS; NERVE GROWTH-FACTOR; HUMAN PLATELETS; PATHOGENESIS; CELLS; NGF;
D O I：
10.1016/j.ancard.2008.11.001
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Neurotrophic-factors research is dominated by neurotrophins (NT): a family of polypeptides which includes molecules Such as Nerve Growth Factor (NGF) and the Brain-Derived Neurotrophic Factor (BDNF). They are homodimeric polypeptides. NTs interact with classes of receptors oil responsive cells: protein-tyrosine kinase-type receptors (Trk family). It is well established that the levels of NT determine the balance between cell survival and apoptosis during neural development. Recently, it has been shown that BDNF played a role it) the etiology of some cardiovascular diseases: induction of angiogenesis in ischemic issues. Plasma BDNF was increased in the circulation in patients With Unstable angina. BDNF was expressed in atheromatous intima and adventitia in human coronary artery. Our own studies Suggest that BDNF serum levels in patients With acute myocardial infarction or under cardiopulmonary bypass could related to platelet activation, oxidative stress and inflammatory response. Thus, investigations of this new factor: BDNF will help to better understand vascular development and may lead to new therapeutic strategies for Some cardiovascular diseases. (C) 2008 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：99 / 103
页数：5
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