THE LATEST INTERLEUKIN: IL-33 THE NOVEL IL-1-FAMILY MEMBER IS A POTENT MAST CELL ACTIVATOR

被引：0
作者：
Castellani, M. L. [1 ,3 ]
Kempuraj, D. J. [2 ]
Salini, V. [1 ]
Vecchiet, J. [4 ]
Tete, S. [5 ]
Ciampoli, C. [5 ]
Conti, F. [6 ]
Cerulli, G. [7 ]
Caraffa, A. [7 ]
Antinolfi, P. [7 ]
Theoharides, T. C. [2 ]
De Amicis, D. [1 ]
Perrella, A. [8 ]
Cuccurullo, C. [9 ]
Boscolo, P. [10 ]
Shaik, Y. [11 ]
机构：
[1] Univ G dAnnunzio, Sch Med, Dept Med & Aging, I-66100 Chieti, Italy
[2] Tufts Univ, Sch Med, Dept Pharmacol & Expt Therapeut, Tufts New England Med Ctr, Boston, MA 02111 USA
[3] Univ G dAnnunzio, Sch Med, Div Immunol, I-66100 Chieti, Italy
[4] Univ G dAnnunzio, Sch Med, Clin Infect Dis, I-66100 Chieti, Italy
[5] Univ G dAnnunzio, Sch Dent, I-66100 Chieti, Italy
[6] Univ G dAnnunzio, Gynecol Div, Chieti, Italy
[7] Univ Perugia, Orthopead Div, I-06100 Perugia, Italy
[8] Cotugno Hosp, Dept Infect Dis, Naples, Italy
[9] Univ G DAnnunzio, Atherosclerosis Prevent Ctr, Chieti, Italy
[10] Univ G dAnnunzio, Dept Biomed Sci, Chieti, Italy
[11] Boston Univ, Sch Med, Dept Med, Boston, MA 02118 USA
来源：
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS | 2009年 / 23卷 / 01期
关键词：
IL-33; interleukins; cytokines; mast cell; NATURAL-KILLER ACTIVITY; EXPRESSION; INFLAMMATION; CYTOKINE; BASOPHILS; RECEPTOR; FOREST;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
IL-33, a member of IL-1 family, induces the differentiation of T-cells (depending on the phosphorylation of MAPKs and NF-kappa B) and is involved in T-cell mediated immune responses. IL-33 is also involved in the production of IL-5, IL-4 and IL-13 and several chemokines. In this editorial we show the importance of IL-33 in allergic diseases and its role as an inflammatory cytokine. In addition, the induction of certain chemokines by IL-33 may candidate this new cytokine as a mediator in inflammatory and autoimmune diseases and may prove to be a therapeutic target for the prevention of these diseases.
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页码：11 / 14
页数：4
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