THE LATEST INTERLEUKIN: IL-33 THE NOVEL IL-1-FAMILY MEMBER IS A POTENT MAST CELL ACTIVATOR

被引：0

作者：

Castellani, M. L. ^{[1
,3
]}

Kempuraj, D. J. ^{[2
]}

Salini, V. ^{[1
]}

Vecchiet, J. ^{[4
]}

Tete, S. ^{[5
]}

Ciampoli, C. ^{[5
]}

Conti, F. ^{[6
]}

Cerulli, G. ^{[7
]}

Caraffa, A. ^{[7
]}

Antinolfi, P. ^{[7
]}

Theoharides, T. C. ^{[2
]}

De Amicis, D. ^{[1
]}

Perrella, A. ^{[8
]}

Cuccurullo, C. ^{[9
]}

Boscolo, P. ^{[10
]}

Shaik, Y. ^{[11
]}

机构：

[1] Univ G dAnnunzio, Sch Med, Dept Med & Aging, I-66100 Chieti, Italy

[2] Tufts Univ, Sch Med, Dept Pharmacol & Expt Therapeut, Tufts New England Med Ctr, Boston, MA 02111 USA

[3] Univ G dAnnunzio, Sch Med, Div Immunol, I-66100 Chieti, Italy

[4] Univ G dAnnunzio, Sch Med, Clin Infect Dis, I-66100 Chieti, Italy

[5] Univ G dAnnunzio, Sch Dent, I-66100 Chieti, Italy

[6] Univ G dAnnunzio, Gynecol Div, Chieti, Italy

[7] Univ Perugia, Orthopead Div, I-06100 Perugia, Italy

[8] Cotugno Hosp, Dept Infect Dis, Naples, Italy

[9] Univ G DAnnunzio, Atherosclerosis Prevent Ctr, Chieti, Italy

[10] Univ G dAnnunzio, Dept Biomed Sci, Chieti, Italy

[11] Boston Univ, Sch Med, Dept Med, Boston, MA 02118 USA

来源：

JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS | 2009年 / 23卷 / 01期

关键词：

IL-33; interleukins; cytokines; mast cell; NATURAL-KILLER ACTIVITY; EXPRESSION; INFLAMMATION; CYTOKINE; BASOPHILS; RECEPTOR; FOREST;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

IL-33, a member of IL-1 family, induces the differentiation of T-cells (depending on the phosphorylation of MAPKs and NF-kappa B) and is involved in T-cell mediated immune responses. IL-33 is also involved in the production of IL-5, IL-4 and IL-13 and several chemokines. In this editorial we show the importance of IL-33 in allergic diseases and its role as an inflammatory cytokine. In addition, the induction of certain chemokines by IL-33 may candidate this new cytokine as a mediator in inflammatory and autoimmune diseases and may prove to be a therapeutic target for the prevention of these diseases.

引用

页码：11 / 14

页数：4

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