BIOCHEMICAL AND PHARMACOLOGICAL STUDY OF VENOM OF THE WOLF SPIDER Lycosa singoriensis

被引：16
|
作者：
Liu, Z. H. [1 ]
Qian, W.
Li, J. [1 ]
Zhang, Y. [1 ]
Liang, S. [1 ]
机构：
[1] Hunan Normal Univ, Coll Life Sci, Changsha 410081, Hunan, Peoples R China
来源：
JOURNAL OF VENOMOUS ANIMALS AND TOXINS INCLUDING TROPICAL DISEASES | 2009年 / 15卷 / 01期
基金：
美国国家科学基金会;
关键词：
spider; Lycosa singoriensis; crude venom; MALDI-TOF; antimicrobial activity; CHINESE BIRD SPIDER; COMBINATORIAL PEPTIDE LIBRARIES; HOST-DEFENSE PEPTIDES; ANTIMICROBIAL PEPTIDES; SELENOCOSMIA-HUWENA; CUPIENNIUS-SALEI; OXYOPININS; CHEMISTS; TOXINS; WANG;
D O I：
10.1590/S1678-91992009000100008
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
The wolf spider Lycosa singoriensis is a large and venomous spider distributed throughout northwestern China. Like other spider venoms, the wolf spider venom is a chemical cocktail. Its protein content is 0.659 mg protein/mg crude venom as determined by the Lowry method. MALDI-TOF analysis revealed that the venom peptides are highly diverse and may be divided into three groups characterized by three independent molecular ranges: 2,000 to 2,500 Da, 4,800 to 5,500 Da and 7,000 to 8,000 Da, respectively. This molecular distribution differs substantially from those of most spider venoms studied so far. This wolf spider venom has low neurotoxic action on mice, but it can induce hemolysis of human erythrocytes. Furthermore,
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页码：79 / 92
页数：14
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