Dammarane Triterpenes as Potential SIRT1 Activators from the Leaves of Panax ginseng

被引：28
作者：
Yang, Jun-Li [1 ]
Ha, Thi-Kim-Quy [1 ]
Dhodary, Basanta [1 ]
Kim, Kuk-Hwa [1 ]
Park, Junsoo [2 ]
Lee, Chul-Ho [3 ]
Kim, Young-Choong [1 ]
Oh, Won-Keun [1 ]
机构：
[1] Seoul Natl Univ, Pharmaceut Sci Res Inst, Coll Pharm, Korea Bioact Nat Mat Bank, Seoul 151742, South Korea
[2] Yonsei Univ, Div Biol Sci & Technol, Wonju 220100, South Korea
[3] Korea Res Inst Biosci & Biotechnol, Lab Anim Ctr, Taejon 305806, South Korea
来源：
JOURNAL OF NATURAL PRODUCTS | 2014年 / 77卷 / 07期
基金：
新加坡国家研究基金会;
关键词：
DISCOVERY; CONSTITUENTS; RESVERATROL; METABOLISM; INHIBITORS; REGULATOR; SAPONINS; SURVIVAL; PLANT; MICE;
D O I：
10.1021/np5002303
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
During a search for SIRT1 activators originating in nature, three new dammarane triterpenes, 6 alpha,20(S)-dihydroxydammar-3,12-dione-24-ene (1), 6 alpha,20(S),24(S)-trihydroxydammar-3,12-dione-25-ene (2), and 6 alpha,20(S),25-trihydroxydammar-3,12-dione-23-ene (3), as well as two known triterpenes, dammar-20(22),24-diene-3 beta,6 alpha,12 beta-triol (4) and 20(S)-ginsenoside Rg(3) (5), were isolated from Panax ginseng leaves. Compounds 1 and 3-5 showed potential as SIRT1 activators, as analyzed by in vitro enzyme-based SIRT1-NAD/NADH and SIRT1-p53 luciferase cell-based assays. They were also found to increase the level of NAD(+)/NADH ratio in HEK293 cells. This study presents a new class of chemical entities that may be able to be developed as SIRT1 activators for antiaging and treatment of age-associated diseases.
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收藏
页码：1615 / 1623
页数：9
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