Account: An introduction to velocity-map imaging mass spectrometry (VMImMS)

被引:8
作者
Bull, James N. [1 ]
Lee, Jason W. L. [1 ]
Gardiner, Sara H. [1 ]
Valiance, Claire [1 ]
机构
[1] Univ Oxford, Dept Chem, Chem Res Lab, Oxford OX1 3TA, England
基金
英国工程与自然科学研究理事会; 欧洲研究理事会;
关键词
imaging mass spectrometry; velocity-map imaging; fragment velocity distributions; molecular fingerprinting; KINETIC-ENERGY SPECTROMETRY; SINGLE-PHOTON IONIZATION; MULTIPHOTON IONIZATION; FEMTOSECOND LASER; HIGH-RESOLUTION; TIME; DYNAMICS; IONS; PHOTODISSOCIATION; FRAGMENTATION;
D O I
10.1255/ejms.1264
中图分类号
O64 [物理化学(理论化学)、化学物理学]; O56 [分子物理学、原子物理学];
学科分类号
070203 ; 070304 ; 081704 ; 1406 ;
摘要
This account introduces a new variant of time-of-flight mass spectrometry, termed velocity-map imaging mass spectrometry (VMImMS). While the ion abundances recorded in conventional ToF-MS measurements are highly useful for molecular quantification and structure determination, the final parent and fragment ion yields are largely blind to the dynamics of the processes in which the ions were formed inside the mass spectrometer. By recording the velocity distribution of each ion in tandem with the mass spectrum, not only can the details of the dissociative ionisation dynamics be unravelled, but the extra dimensions of information can be used for enhanced molecular fingerprinting, separating contributions from ions with identical mass-to-charge ratio and resolving components within mixtures, to name but a few examples. Measuring ion-velocity distributions within a mass spectrometry measurement is not new, but incorporating imaging techniques developed within the reaction dynamics community provides vastly improved velocity resolution for all ions simultaneously in a single-stage instrument. This account provides an introduction to VMImMS, outlines the fundamental instrumentation and detector requirements and the challenges associated with developing the method further, and details proof-of-concept work from our laboratory on a number of potential applications of the technique.
引用
收藏
页码:117 / 129
页数:13
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