VanD-type glycopeptide-resistant Enterococcus faecium BM4339

被引：180

作者：

Perichon, B ^{[1
]}

Reynolds, P ^{[1
]}

Courvalin, P ^{[1
]}

机构：

[1] UNIV CAMBRIDGE,DEPT BIOCHEM,CAMBRIDGE CB2 1QW,ENGLAND

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1997年 / 41卷 / 09期

关键词：

D O I：

10.1128/AAC.41.9.2016

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Enterococcus faecium BM4339 was constitutively resistant to vancomycin (MIG, 64 mu g/ml) and to low levels of teicoplanin (MIG, 4 mu g/ml). A 605-bp product obtained with the V1 and V2 primers for amplification of genes encoding D-Ala:D-Ala ligases and related glycopeptide resistance proteins was sequenced after cloning. The deduced amino acid sequence had 69% identity with VanA and VanB and 43% identity with VanC, consistent with the finding that BM4339 synthesized peptidoglycan precursors terminating in D-lactate. This new type of glycopeptide resistance phenotype was designated VanD.

引用

页码：2016 / 2018

页数：3

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